Issue 34, 2020

Exosome: a significant nano-scale drug delivery carrier

Abstract

In recent years, due to the limitations of the nature of therapeutic agents, many synthetic nano-delivery systems have emerged to enhance the efficacy of drugs. Extracellular vesicles are currently a class of natural nano-scale drug carriers released by cells. As a tiny vesicle with a lipid bilayer membrane that can be secreted by most cells in the body, exosomes carry and transmit important signal molecules, Therefore, they have been a research hotspot in biomedicine and biomaterials due to their size advantages and huge potential in drug therapy. Many people are optimistic about the clinical application prospects of exosomes and are actively exploring the broad functions of exosomes and developing exosome therapeutic agents to make positive contributions to human health. In this review, we provide basic knowledge and focus on summarizing the advantages of exosomes as drug carriers, methods of loading drugs, targeting strategies, in vivo and in vitro tracing methods, and some of the latest developments in exosomes as drug carriers. In particular, the review provides an outlook for this field.

Graphical abstract: Exosome: a significant nano-scale drug delivery carrier

Article information

Article type
Review Article
Submitted
16 Чер 2020
Accepted
15 Лип 2020
First published
17 Лип 2020

J. Mater. Chem. B, 2020,8, 7591-7608

Exosome: a significant nano-scale drug delivery carrier

H. Peng, W. Ji, R. Zhao, J. Yang, Z. Lu, Y. Li and X. Zhang, J. Mater. Chem. B, 2020, 8, 7591 DOI: 10.1039/D0TB01499K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements