Construction of axially chiral molecules enabled by photoinduced enantioselective reactions

Abstract

Axially chiral molecular scaffolds are widely found in pharmaceutical molecules, functionalized materials, and chiral ligands. The synthesis of these compounds has garnered considerable interest from both academia and industry. The construction of such molecules, enabled by transition metal catalysis and organocatalysis under thermodynamic conditions, has been extensively studied and well-reviewed. In recent years, photoinduced enantioselective reactions have emerged as powerful methods for the catalytic construction of axial chirality. In this review, we provide an overview of various synthetic strategies for the photoinduced construction of axial chirality, with a specific focus on reaction design and catalytic mechanisms. Additionally, we discuss the limitations of current methods and highlight future directions in this field.