A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy

Eduardo Guimarães Vieira; Rodrigo Boni Fazzi; Daniel O. T. A. Martins; Alena M. Sheveleva; Floriana Tuna; Ana Maria da Costa Ferreira

doi:10.1039/D2RA07266A

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A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy†

Eduardo Guimarães Vieira,

^ab Rodrigo Boni Fazzi,^a Daniel O. T. A. Martins,

^b Alena M. Sheveleva,^b Floriana Tuna

*^b and Ana Maria da Costa Ferreira

*^a

Author affiliations

* Corresponding authors

^a Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, 05508-000 São Paulo-SP, Brazil
E-mail: amdcferr@iq.usp.br

^b EPSRC National EPR Facility, Department of Chemistry and Photon Science Institute, University of Manchester, Manchester M13 9PL, UK
E-mail: floriana.tuna@manchester.ac.uk

Abstract

A novel strategy of improving cytotoxicity against metastatic melanoma cells using an oxindolimine copper(II) complex immobilized and dimerized on a modified Polyhedral Oligomeric Silsesquioxane (POSS) matrix was developed, as revealed by electron paramagnetic resonance (EPR) spectroscopy. An assured correlation between continuous-wave (CW) and pulsed EPR spectroscopies provided a complete characterization of the actual active species, its coordination environment, as well as the efficiency/selectivity of the bioconjugate materials.

This article is part of the themed collection: Celebrating the 200th Anniversary of the University of Manchester

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DOI: https://doi.org/10.1039/D2RA07266A
Article type: Paper
Submitted: 15 Лис 2022
Accepted: 20 Бер 2023
First published: 24 Бер 2023
This article is Open Access

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RSC Adv., 2023,13, 9715-9719

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A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy

E. G. Vieira, R. B. Fazzi, D. O. T. A. Martins, A. M. Sheveleva, F. Tuna and A. M. da Costa Ferreira, RSC Adv., 2023, 13, 9715 DOI: 10.1039/D2RA07266A

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A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy†

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