Issue 4, 2023

A metal-free protocol for the preparation of amines using ammonia borane under mild conditions

Abstract

A mild and convenient reductive amination protocol for the synthesis of structurally diverse secondary and tertiary amines as well as N-methylated products under metal-free conditions is presented. This one-pot protocol works efficiently at room temperature using ammonia borane as the reductant and is applicable to a wide range of substrates, including chiral amines and amino acid derivatives. The synthetic utility and practicability of this methodology is demonstrated by gram-scale reactions and selected synthesis of current drug molecules.

Graphical abstract: A metal-free protocol for the preparation of amines using ammonia borane under mild conditions

Supplementary files

Article information

Article type
Research Article
Submitted
07 Гру 2022
Accepted
29 Гру 2022
First published
29 Гру 2022

Org. Chem. Front., 2023,10, 970-976

A metal-free protocol for the preparation of amines using ammonia borane under mild conditions

X. Li, Y. Hu, A. M. Alenad, B. Zhou, Z. Ma, J. Gao, R. V. Jagadeesh and M. Beller, Org. Chem. Front., 2023, 10, 970 DOI: 10.1039/D2QO01938H

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