Issue 7, 2023

Dextran/eudragit S-100 based redox sensitive nanoparticles for colorectal cancer therapy

Abstract

Herein, we present disulfide crosslinked dextran/eudragit S-100 nanoparticles (DEEU NPs) (≈55 nm) for colorectal cancer treatment. These redox environment sensitive DEEU NPs are synthesized by simple oxidation of thiolated polymers in air. This approach allows avoiding the use of any additional chemical crosslinker. These DEEU NPs have high encapsulation efficiency for the doxorubicin (DOX) model drug (≈95%). The prepared DEEU NPs are redox sensitive owing to disulfide units and exhibit ≈80% DOX release in the reducing environment of GSH. Additionally, DOX-DEEU NPs display enhanced cytotoxicity for HCT116 cancer cells as compared to free DOX. Annexin V staining results also support the higher anticancer efficiency of DOX-DEEU NPs via induction of apoptosis. In vivo biodistribution results demonstrate that DEEU NPs can remain in the colon region for up to 24 hours. These results indicate that DEEU NPs can act as a promising platform for colorectal cancer treatment.

Graphical abstract: Dextran/eudragit S-100 based redox sensitive nanoparticles for colorectal cancer therapy

Supplementary files

Article information

Article type
Paper
Submitted
10 Лис 2022
Accepted
18 Січ 2023
First published
19 Січ 2023

Nanoscale, 2023,15, 3273-3283

Dextran/eudragit S-100 based redox sensitive nanoparticles for colorectal cancer therapy

A. Gupta, A. Dhiman, A. Sood, R. Bharadwaj, N. Silverman and G. Agrawal, Nanoscale, 2023, 15, 3273 DOI: 10.1039/D3NR00248A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements