SARS-CoV-2 suppression depending on the pH of graphene oxide nanosheets

Md. Saidul Islam; Masahiro Fukuda; Md. Jakir Hossain; Nurun Nahar Rabin; Ryuta Tagawa; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Yoshihiro Sekine; Terumasa Ikeda; Shinya Hayami

doi:10.1039/D3NA00084B

SARS-CoV-2 suppression depending on the pH of graphene oxide nanosheets†

Md. Saidul Islam,

^ab Masahiro Fukuda,^b Md. Jakir Hossain,^cd Nurun Nahar Rabin,^ab Ryuta Tagawa,^a Mami Nagashima,^e Kenji Sadamasu,^e Kazuhisa Yoshimura,^e Yoshihiro Sekine,

^f Terumasa Ikeda*^d and Shinya Hayami

*^abg

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* Corresponding authors

^a Department of Chemistry, Faculty of Advanced Science and Technology, Kumamoto University, 2-39-1 Kurokami, Kumamoto 860-8555, Japan
E-mail: hayami@kumamoto-u.ac.jp

^b Institute of Industrial Nanomaterials, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, Japan

^c Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan

^d Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-0811, Japan

^e Tokyo Metropolitan Institute of Public Health, Tokyo, Japan

^f Priority Organization for Innovation and Excellence, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, Japan

^g International Research Center for Agricultural and Environmental Biology (IRCAEB), 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, Japan

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inactivation of pH-dependent graphene oxide (GO) nanosheets is presented. The observed virus inactivation using an authentic virus (Delta variant) and different GO dispersions at pH 3, 7, and 11 suggests that the higher pH of the GO dispersion yields a better performance compared to that of GO at neutral or lower pH. The current findings can be ascribed to the pH-driven functional group change and the overall charge of GO, favorable for the attachment between GO nanosheets and virus particles.

This article is part of the themed collection: Popular Advances

Nanoscale Advances

SARS-CoV-2 suppression depending on the pH of graphene oxide nanosheets†

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SARS-CoV-2 suppression depending on the pH of graphene oxide nanosheets

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