Issue 22, 2020

pH-Sensitive nanotheranostics for dual-modality imaging guided nanoenzyme catalysis therapy and phototherapy

Abstract

Triple-negative breast cancer shows resistance to conventional radiotherapies and chemotherapies, and few molecular targeted therapies are currently available for this malignancy in clinical settings. In this work, a theranostic nanosystem with a core–shell structure was synthesized through self-assembly of amphiphilic macromolecules, which can be used in effective catalysis therapy and phototherapy. Herein, we report that superparamagnetic iron oxide nanocrystals and IR780 dye were effectively loaded into the hydrophobic core of the nanosystem, which enabled dual-modality magnetic resonance imaging and near-infrared fluorescence imaging. Furthermore, on the hydrophilic crown, the neighboring carboxylic acid-based amide linkage showed charge conversion properties in the tumor acidic microenvironment and endowed the system with targeted diagnosis and delivery. Upon light excitation, this theranostic system exerted synergistic anti-cancer activity through the nano-enzyme catalysis effect enhanced phototherapy in a triple-negative 4T1 breast cancer model. Furthermore, there were no obvious side-effects. The results of our study demonstrate the great potential of this theranostic nanosystem in cancer diagnosis and therapy.

Graphical abstract: pH-Sensitive nanotheranostics for dual-modality imaging guided nanoenzyme catalysis therapy and phototherapy

Supplementary files

Article information

Article type
Paper
Submitted
02 Гру 2019
Accepted
11 Лют 2020
First published
11 Лют 2020

J. Mater. Chem. B, 2020,8, 4859-4869

pH-Sensitive nanotheranostics for dual-modality imaging guided nanoenzyme catalysis therapy and phototherapy

S. Wang, J. Mao, H. Liu, S. Huang, J. Cai, W. Gui, J. Wu, J. Xu, J. Shen and Z. Wang, J. Mater. Chem. B, 2020, 8, 4859 DOI: 10.1039/C9TB02731A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements