Issue 54, 2016

AlCl3-mediated heteroarylation-cyclization strategy: one-pot synthesis of fused quinoxalines containing the central core of Lamellarin D

Abstract

An inexpensive, practical and one-pot method has been developed for the synthesis of quinoxalines fused with pyrano[3,4-b]indole, the central core of Lamellarin D. The methodology involved construction of the central pyranone ring via an AlCl3-mediated heteroarylation-cyclization method. A number of compounds were prepared using this methodology, some of which were converted to the corresponding indol-3-ylquinoxaline derivatives. Several of the pyrano[3,4-b]indole fused quinoxalines showed promising growth inhibition of cervical and lung cancer cells and good interactions with topoisomerase I in silico.

Graphical abstract: AlCl3-mediated heteroarylation-cyclization strategy: one-pot synthesis of fused quinoxalines containing the central core of Lamellarin D

Supplementary files

Article information

Article type
Communication
Submitted
22 Бер 2016
Accepted
08 Тра 2016
First published
10 Тра 2016

RSC Adv., 2016,6, 48324-48328

AlCl3-mediated heteroarylation-cyclization strategy: one-pot synthesis of fused quinoxalines containing the central core of Lamellarin D

K. S. Kumar, S. R. Meesa, B. Rajesham, B. Bhasker, M. A. Ashfaq, A. A. Khan, S. S. Rao and M. Pal, RSC Adv., 2016, 6, 48324 DOI: 10.1039/C6RA07507J

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