Use of a new water-soluble Zn sensor to determine Zn affinity for the amyloid-β peptide and relevant mutants

Sabrina Noël; Susana Bustos Rodriguez; Stéphanie Sayen; Emmanuel Guillon; Peter Faller; Christelle Hureau

doi:10.1039/C4MT00016A

Use of a new water-soluble Zn sensor to determine Zn affinity for the amyloid-β peptide and relevant mutants†

Sabrina Noël,^ab Susana Bustos Rodriguez,^ab Stéphanie Sayen,^c Emmanuel Guillon,^c Peter Faller^ab and Christelle Hureau*^ab

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* Corresponding authors

^a CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse Cedex 4, France

^b Université de Toulouse, UPS, INPT, F-31077 Toulouse Cedex 4, France
E-mail: christelle.hureau@lcc-toulouse.fr

^c Institut de Chimie Moléculaire de Reims (ICMR, CNRS UMR 7312), Groupe de Chimie de Coordination, Université de Reims Champagne-Ardenne, BP 1039, 51687 Reims Cedex 2, France

Abstract

Evaluation of Zn affinity for the amyloid-β peptide involved in Alzheimer's disease and its modified counterparts is reported. This was made possible by the use of a new water-soluble chelator, the properties of which have also been described. Changes in the peptide sequence that impact Zn affinity are briefly discussed.

This article is part of the themed collection: Zinc in the Biosciences

Metallomics

Use of a new water-soluble Zn sensor to determine Zn affinity for the amyloid-β peptide and relevant mutants†

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