Issue 34, 2024

Integrated design and application of stimuli-responsive metal–organic frameworks in biomedicine: current status and future perspectives

Abstract

In recent years, metal–organic frameworks (MOFs) have garnered widespread attention due to their distinctive attributes, such as high surface area, tunable properties, biodegradability, extremely low density, high loading capacity, diverse chemical functionalities, thermal stability, well-defined pore sizes, and molecular dimensions. Increasingly, biomedical researchers have turned their focus towards their multifaceted development. Among these, stimuli-responsive MOFs, with their unique advantages, have captured greater interest from researchers. This review will delve into the merits and drawbacks of both endogenous and exogenous stimuli-responsive MOFs, along with their application directions. Furthermore, it will outline the characteristics of different synthesis routes of MOFs, exploring various design schemes and modification strategies and their impacts on the properties of MOF products, as well as how to control them. Additionally, we will survey different types of stimuli-responsive MOFs, discussing the significance of various MOF products reported in biomedical applications. We will categorically summarize different strategies such as anticancer therapy, antibacterial treatment, tissue repair, and biomedical imaging, as well as insights into the development of novel MOFs nanomaterials in the future. Finally, this review will conclude by summarizing the challenges in the development of stimuli-responsive MOFs in the field of biomedicine and providing prospects for future research endeavors.

Graphical abstract: Integrated design and application of stimuli-responsive metal–organic frameworks in biomedicine: current status and future perspectives

Article information

Article type
Review Article
Submitted
08 Кві 2024
Accepted
21 Лип 2024
First published
23 Лип 2024

J. Mater. Chem. B, 2024,12, 8235-8266

Integrated design and application of stimuli-responsive metal–organic frameworks in biomedicine: current status and future perspectives

H. Liu, F. Xing, P. Yu, S. Shakya, K. Peng, M. Liu, Z. Xiang and U. Ritz, J. Mater. Chem. B, 2024, 12, 8235 DOI: 10.1039/D4TB00768A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements