Issue 3, 2024

DNA nanotechnology-based nucleic acid delivery systems for bioimaging and disease treatment

Abstract

Nucleic acids, including DNA and RNA, have been considered as powerful and functional biomaterials owing to their programmable structure, good biocompatibility, and ease of synthesis. However, traditional nucleic acid-based probes have always suffered from inherent limitations, including restricted cell internalization efficiency and structural instability. In recent years, DNA nanotechnology has shown great promise for the applications of bioimaging and drug delivery. The attractive superiorities of DNA nanostructures, such as precise geometries, spatial addressability, and improved biostability, have enabled them to be a novel category of nucleic acid delivery systems for biomedical applications. In this review, we introduce the development of DNA nanotechnology, and highlight recent advances of DNA nanostructure-based delivery systems for cellular imaging and therapeutic applications. Finally, we propose the challenges as well as opportunities for the future development of DNA nanotechnology in biomedical research.

Graphical abstract: DNA nanotechnology-based nucleic acid delivery systems for bioimaging and disease treatment

Article information

Article type
Minireview
Submitted
28 Жов 2023
Accepted
21 Гру 2023
First published
23 Гру 2023

Analyst, 2024,149, 599-613

DNA nanotechnology-based nucleic acid delivery systems for bioimaging and disease treatment

Z. Sun, Y. Ren, W. Zhu, Y. Xiao and H. Wu, Analyst, 2024, 149, 599 DOI: 10.1039/D3AN01871G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements