Issue 38, 2022

Single laser activated photothermal/photodynamic dual-modal cancer phototherapy by using ROS-responsive targeting flower-like ruthenium nanoparticles

Abstract

Phototherapy, which mainly includes photothermal therapy (PTT) and photodynamic therapy (PDT), is one of the most promising strategies for cancer therapeutics. Ruthenium as a metal nanomaterial shows great potential as a phototherapy agent. Herein, we developed flower-like ruthenium nanoparticles (FRuNPs) to enhance cancer phototherapy. Compared with spherical ruthenium nanoparticles (SRuNPs) of a similar size, FRuNPs exhibited more enhanced near-infrared (NIR) absorption. FRuNPs exhibited a superior photothermal effect, which significantly improved the efficiency of PTT. Intracellular reactive oxide species (ROS) generation was recognized as the primary mechanism of PDT treatment. FRuNPs mediated the generation of ROS when exposed to 808 nm laser irradiation. Moreover, with the synergistic effect of PTT and PDT in FRuNPs, the phototherapeutic effects were obviously enhanced. In vitro phototherapy of MCF-7 cells in the presence of FRuNPs led to nearly 100% cell death under irradiation with an 808 nm laser. And in vivo FRuNPs further showed the capacity of in completely clearing the tumor tissues and improving the hypoxia environment with 14 days for interval laser irradiation. These results indicate that FRuNPs have versatile potential for tumor phototherapy.

Graphical abstract: Single laser activated photothermal/photodynamic dual-modal cancer phototherapy by using ROS-responsive targeting flower-like ruthenium nanoparticles

Associated articles

Article information

Article type
Paper
Submitted
20 Чер 2022
Accepted
21 Сер 2022
First published
25 Сер 2022

J. Mater. Chem. B, 2022,10, 7760-7771

Single laser activated photothermal/photodynamic dual-modal cancer phototherapy by using ROS-responsive targeting flower-like ruthenium nanoparticles

Y. Liu, J. Huang and J. Liu, J. Mater. Chem. B, 2022, 10, 7760 DOI: 10.1039/D2TB01276F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements