Issue 18, 2019

Biophysical analysis of cancer stem cell-potent copper(ii) coordination complexes

Abstract

Copper(II) coordination complexes, 1 and 2, containing nonsteroidal anti-inflammatory drugs (NSAIDs) potently kill breast cancer stem cells (CSCs) and bulk breast cancer cells. Although detailed biological studies have been conducted to shed light on their mechanism of cytotoxicity, little is known about their molecular level mechanism of action. This biophysical study, aided by the preparation of a fluorophore-containing analogue, 3, reveals that the complexes operate by undergoing reduction to a copper(I) form and releasing the associated NSAIDs.

Graphical abstract: Biophysical analysis of cancer stem cell-potent copper(ii) coordination complexes

Supplementary files

Article information

Article type
Communication
Submitted
28 Лис 2018
Accepted
02 Січ 2019
First published
02 Січ 2019

Dalton Trans., 2019,48, 5892-5896

Biophysical analysis of cancer stem cell-potent copper(II) coordination complexes

P. Zheng, A. Eskandari, C. Lu, K. Laws, L. Aldous and K. Suntharalingam, Dalton Trans., 2019, 48, 5892 DOI: 10.1039/C8DT04706E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements