Herein, we present a novel approach for the preparation of alkynyl cyclopropa[c]coumarin derivatives with medium to good yields utilizing propargyl sulfonium salts as C1 synthons.
A planned total synthesis of photosynthetic tetrapyrrole macrocycles installs essential stereochemical features in early precursors via established asymmetric methodology.
A Cr(II)-mediated highly diastereoselective Nozaki–Hiyama allylation has been employed in the efficient first asymmetric total synthesis of two 1,10-seco-guaianolides.
A concise and practical one-pot total synthesis of TMC-205 together with the formal synthesis of a series of novel meroterpenoid natural products was achieved via a super-ideal strategy.
Metal-free synthesis of medicinally important carbamoylated dihydroquinolinones using readily available, cheap and environment-friendly materials with good to excellent yields.