Xiangying Li, Yuanyuan Liu, Wen Shao, Deling Jiang, Xupeng Huang, Zihe Rao, Wei Peng and Yuying Fang
RSC Med. Chem., 2026,17, 1066-1082
Abstract
Integrated virtual and biological screening guided the design and synthesis of 50 novel pyrimido[1,2-a]imidazole derivatives, leading to the discovery of potent Pks13-TE inhibitor 34 (IC50 = 0.23 μM).
Yuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang and Xiaoyan Pan
RSC Med. Chem., 2024,15, 3507-3528
Abstract
In continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.
Yousry A. Ammar, Ahmed Ragab, M. A. Migahed, S. Al-Sharbasy, Mohamed A. Salem, Omnia Karem M. Riad, Heba Mohammed Refat M. Selim, Gehad A. Abd-elmaksoud and Moustafa S. Abusaif
RSC Adv., 2023,13, 27363-27384
Abstract
New 2-oxo-pyridines containing thiophene/furan scaffold targeting LasR gene on P. aeruginosa using green synthesis approach.
Virginia Pontecorvi, Andrea Angeli, Luigi Cutarella, Mattia Mori, Daniela Secci, Michele Coluccia, Simone Carradori, Anna Troiani, Federico Pepi, Chiara Salvitti, Alessia Di Noi, Mattia Spano, Francesca Arrighi, Elena De Falco, Antonella Bordin, Emanuela Berrino, Arianna Granese, Paola Chimenti, Paolo Guglielmi and Claudiu T. Supuran
RSC Med. Chem., 2025,16, 3603-3621
Abstract
Development of the novel coumalic acid-based selective hCA IX and XII inhibitors.
Kailash Jangid, Bharti Devi, Ruby Dahiya, Jayapriya Mishra, Vinay Kumar, Jasvinder Singh Bhatti, Suresh Thareja and Vinod Kumar
RSC Med. Chem., 2025,16, 6153-6172
Abstract
Multitarget directed ligands represent an innovative strategy in the management of Alzheimer's disease (AD) by addressing its multifactorial etiology.