A practical approach for preparing 3,4-fused 2-quinolones has been disclosed. The Rh(III)-catalyzed highly selective alkenyl C–H activation/annulation of 4-amino-2-quinolones was achieved via an unprecedented reversible alkyne insertion.
This manuscript describes a switchable synthesis of biologically active C4-ethylaminoindole and C7-aminoindoline scaffolds by controlling β-carbon elimination, utilizing aziridine as a C–H ethylamination reagent via C–N bond cleavage.
Zr and Hf pyridylamides reversibly insert nitriles into M–CAr bond and release them back with cleavage of the formed C–C bond, regeneration of the M–CAr bond and the free nitrile: a first example of β-aryl elimination in early transition metals.
Organoborons have emerged as a class of privileged building blocks in modern organic synthesis, enabling unparalleled molecular diversity and serving as versatile carboxylic acid bioisosteres with profound implications in drug discovery.
Unprecedentedly preferential reduction of unstrained C(sp3)–C(sp3) bond over ketone, hydrogenative [2+2+2]-cycloreversion of 2,4-diacylcyclohexanols, and cyclizative degradation of poly(vinylketone) have been achieved by organolanthanide catalysis.