In this highlight, recent advances in the synthesis of highly substituted imidazolidines, chiral imidazolidines with high diastereoselectivities and enantioselectivities, bis-imidazolidines, and spiro-imidazolidines are presented.
The asymmetric catalytic synthesis of 1,2-diamines has received considerable interest, due to their presence in biologically active compounds and their applications for the development of synthetic building blocks, chiral ligands and organocatalysts.
A rhodium or copper catalyzed (5 + 1) cycloaddition of diazooxindoles with imidazolidines is reported, offering a series of structurally novel piperazine-spirooxindoles. The asymmetric version has also been realized under Cu(II)/SaBOX system.
We describe herein easily oxidizable 2-substituted-1,3-imidazolidines for the photocatalyzed generation of (substituted) alkyl radicals for the forging of C(sp3)–C(sp3) bonds under metal-free conditions.
A metal-free, conjugated organic polymer (TPA-PQ)-catalyzed intramolecular C–H functionalization strategy for the synthesis of imidazolidines in the presence of light and O2 is reported.