A sustainable electrochemical approach for site-selective C–H mono and bis-chalcogenation (sulfenylation or selenylation) of indolizine frameworks is described.
This review highlights advances in one-pot multicomponent synthesis of naphthyridine derivatives, focusing on efficient, atom-economical methods, diverse scaffolds and mechanistic insights fostering innovation in organic synthesis.
The activation of AMPK has emerged as a promising therapeutic approach for the treatment of metabolic diseases.
Gold(I) terpyridine derivatives exhibiting exceptional cytotoxic activity against critical cancer types are elucidated. Significantly, these compounds demonstrate dual functionality by interacting with DNA and inhibiting TrxR.
A series of novel matrine-pyrazole derivatives were designed and synthesized through structural modification of the natural alkaloid matrine to enhance its antitumor efficacy.