Nanozymes for clean energy catalysis: unlocking potential, progress and perspectives

Harshita, Murali Sastry and Shanthi Priya Samudrala

Nanoscale, 2026, 18, 1121
DOI: 10.1039/D5NR04138D

Nanozyme-enabled cancer theranostics: bridging enzyme mimicry and material intelligence

Yupeng Wang, Xinxin Sun, Shunfeng Wang, Zhixiao Zhang, Jin Sun, Cong Luo, Zhonggui He and Shenwu Zhang

Mater. Horiz., 2025, 12, 8895
DOI: 10.1039/D5MH01000D

Advancing metallic nanozymes for multiplexed multimodal biosensing in early disease diagnostics

Batrisyia Safwah Mohd Salleh and Minhaz Uddin Ahmed

Nanoscale Horiz., 2026, 11, 953
DOI: 10.1039/D5NH00691K

Fe-doped biodegradable dendritic mesoporous silica nanoparticles for starvation therapy and photothermal-enhanced cascade catalysis in tumor therapy

Mengwei Ye, Weikang Zhang, Hongwei Xu, Peiyu Xie, Luming Song, Xiaohan Sun, Yian Li, Siling Wang and Qinfu Zhao

Journal of Colloid and Interface Science, 2025, 678, 378
DOI: 10.1016/j.jcis.2024.08.172

Nanozymes in biomedicine: Unraveling trends, research foci, and future trajectories via bibliometric insights (from 2007 to 2024)

Siyang Cao, Yingchen Pang, Yihao Wei, Deli Wang, Ao Xiong, Jun Yang and Hui Zeng

International Journal of Biological Macromolecules, 2025, 309, 142798
DOI: 10.1016/j.ijbiomac.2025.142798

Carbon-based nanozymes for cancer therapy and diagnosis: A review

Marco Cordani, Jesús Fernández-Lucas, Arezoo Khosravi, Ehsan Nazarzadeh Zare, Pooyan Makvandi, Ali Zarrabi and Siavash Iravani

International Journal of Biological Macromolecules, 2025, 297, 139704
DOI: 10.1016/j.ijbiomac.2025.139704

Machine Learning‐Assisted High‐Throughput Screening of Nanozymes for Ulcerative Colitis

Xianguang Zhao, Yixin Yu, Xudong Xu, Ziqi Zhang, Zhen Chen, Yubo Gao, Liang Zhong, Jiajie Chen, Jiaxin Huang, Jie Qin, Qingyun Zhang, Xuemei Tang, Dongqin Yang and Zhiling Zhu

Advanced Materials, 2025, 37
DOI: 10.1002/adma.202417536

Advanced wound healing with Stimuli-Responsive nanozymes: mechanisms, design and applications

Xiaoyang Liu, Huihui Zhang, Lianglong Chen, Zesen Zheng, Wenwen Li, Chaoyang Huang, Hai Zhou, Yanqi Chen, Ziwei Jiang, Jiaqi Liang, Qiuyi Yu and Lei Yang

J Nanobiotechnol, 2025, 23
DOI: 10.1186/s12951-025-03558-w

Smart Designer Nanozymes for Precision Cancer Therapy: Recent Advances and Prospects

Atta Ullah Khan, Muhammad Naeem Kiani, Noor Ul Huda and Yongdong Jin

ACS Appl. Mater. Interfaces, 2026, 18, 4632
DOI: 10.1021/acsami.5c21149

Amino acid regulation of peroxidase-like activity of Cu2O nanozyme for detection of tetracycline antibiotics

Yueqiang Wang and Shengwei Sun

Anal Bioanal Chem, 2025, 417, 3813
DOI: 10.1007/s00216-025-05904-1

Luminescent Nanozyme-Based Sensors for Bacteria Detection

D. S. Chumakov, S. S. Evstigneeva and O. I. Guliy

Appl Biochem Microbiol, 2024, 60, 1022
DOI: 10.1134/S0003683824606139

Advancement and Perspective of Nanozyme in Cancer Diagnosis and Treatment Applications

Ziqi Ding, Qi Sang, Yuning Wang and Kun Qian

ACS Appl. Mater. Interfaces, 2025
DOI: 10.1021/acsami.5c10701

Advances and applications of metal-organic framework-based hydrolytic nanozymes

Wen Peng, Xiang-Lei Chang, Wei-Feng Wang and Jun-Li Yang

Materials Today Chemistry, 2026, 53, 103513
DOI: 10.1016/j.mtchem.2026.103513

Superoxide dismutase-mimetic nanozymes: A promising alternative to natural superoxide dismutases for biomedical and industrial applications

Hoda Zamanian Dastmalchi, Fariba Dashtestani and Hedayatollah Ghourchian

Colloids and Surfaces B: Biointerfaces, 2026, 257, 115138
DOI: 10.1016/j.colsurfb.2025.115138

Research Trends and Hot Topics of Nanozymes in Wound Care: A Bibliometric Analysis

Shuilan Bao, Yiren Wang, Yuxin Zhong, Shouying Chen, Li Yao, Yamei Luo, Ping Zhou and Yun Zhou

Tissue Engineering Part C: Methods, 2025, 31, 85
DOI: 10.1089/ten.tec.2024.0329

Smartphone-integrated Nanozyme approaches for rapid and on-site detection: Empowering smart food safety

Flomo Peter Gbonyea, Jiahang Wu, Mengru Li, Mengdi Liang, Mingdao Zhang, Xiaoyan Zhu, Xiangqian Li, Shuai He and Pei Liu

Food Chemistry, 2025, 486, 144678
DOI: 10.1016/j.foodchem.2025.144678

Nanozymes: Promising frontiers in detection and nanoremediation of environmental pollutants

Herbert Che Mughe, Henrick A. Kola, Mahmut S. Ersan, Diane C. Darland and Julia Xiaojun Zhao

Energy & Environmental Sustainability, 2026, 2, 100070
DOI: 10.1016/j.eesus.2026.100070

Nanozymes: a dual approach to bacterial colorimetric and luminescent detection and to bacterial pathogen killing

Olga I. Guliy, Daniil S. Chumakov, Stella S. Evstigneeva, Qingyun Liu and Elena G. Zavyalova

Biosensors and Bioelectronics, 2025, 288, 117835
DOI: 10.1016/j.bios.2025.117835

Design and performance analysis of multi-enzyme activity-doped nanozymes assisted by machine learning

Fuguo Ge, Yonghui Gao, Yujie Jiang, Yijie Yu, Qiang Bai, Yun Liu, HuiBin Li and Ning Sui

Colloids and Surfaces B: Biointerfaces, 2025, 248, 114468
DOI: 10.1016/j.colsurfb.2024.114468

A dual-mode sensing system for xanthine oxidase detection based on nitrogen-doped carbon dots and iron-cobalt oxide nanosheets

Junshu Wang, Jinying Liu, Chenyu Zhou, Yuntai Lv, Nan Wang, Meini Li and Xingguang Su

Sensors and Actuators B: Chemical, 2024, 415, 135954
DOI: 10.1016/j.snb.2024.135954

Emerging Technologies in Food Safety: AI-Powered, Nano-enabled, and Biosensor-Based Strategies for Rapid Contaminant Detection

Shikha Pandhi, Nilima Kumari, Amit Jain and Vinay Sharma

Food Anal. Methods, 2025, 18, 2010
DOI: 10.1007/s12161-025-02844-5

Catalytic activity nanozymes for microbial detection

Zheng Jin, Guodong Huang, Yang Song, Chibo Liu, Xiaohua Wang and Kai Zhao

Coordination Chemistry Reviews, 2025, 534, 216578
DOI: 10.1016/j.ccr.2025.216578

Two Birds, One Stone: Smart MOF Nanozymes for Dual Catalysis and Theranostics

Mohammed Ali Dheyab, Wesam Abdullah, Azlan Abdul Aziz, Nik Noor Ashikin Nik Ab Razak, Nursakinah Suardi, Saleh T. Alanezi, Mahmood S. Jameel, Farhank Saber Braim, Firas Fohely, Pegah Moradi Khaniabadi, Nazila Oladzadabbasabadi and Mehran Ghasemlou

Small, 2025, 21
DOI: 10.1002/smll.202509992

A triple-mode sensing platform for xanthine oxidase activity monitoring and inhibitor screening based on fluorescent trimetal-organic framework with efficient peroxidase-mimetic activity

Sikai Wang, Weiping Liu, Wen Li, Lei Wang, Xiaojun Luo, Guoqi Zhang and Yan Zhao

Analytica Chimica Acta, 2026, 1384, 344931
DOI: 10.1016/j.aca.2025.344931

Intelligent nanosensors towards pathogenic bacteria and their derivatives for infectious disease diagnosis

Jianyu Yang, Yaxuan Tang, Yuxi Zhang, Xin Wang, Hao Lu, Chunxian Guo and Ting Yang

TrAC Trends in Analytical Chemistry, 2026, 200, 118830
DOI: 10.1016/j.trac.2026.118830

Exploring the synergy between technique and timescale in simulations: From biomolecules to biomaterials

Apramita Chand

J Chem Sci, 2026, 138
DOI: 10.1007/s12039-026-02481-3

Progress in the Computer‐Aided Analysis in Multiple Aspects of Nanocatalysis Research

Lin Fan, Yilei Shen, Doudou Lou and Ning Gu

Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202401576

Machine-Learning-Assisted Nanozyme-Based Sensor Arrays: Construction, Empowerment, and Applications

Jinjin Liu, Xinyu Chen, Qiaoqiao Diao, Zheng Tang and Xiangheng Niu

Biosensors, 2025, 15, 344
DOI: 10.3390/bios15060344

Deep Learning-Enhanced Nanozyme-Based Biosensors for Next-Generation Medical Diagnostics

Seungah Lee, Nayra A. M. Moussa and Seong Ho Kang

Biosensors, 2025, 15, 571
DOI: 10.3390/bios15090571

Carbocation charge as an interpretable descriptor for the catalytic activity of hydrolytic nanozymes

Zhen Chen, Ziqi Zhang, Yixin Yu, Yu Guo, Jing Liu and Zhiling Zhu

Journal of Colloid and Interface Science, 2025, 683, 858
DOI: 10.1016/j.jcis.2024.12.191

Palladium-powered nanozymes: A paradigm shift in precision medicine

Akanksha Deshwal and Ravi Mani Tripathi

Chemical Engineering Journal, 2025, 522, 168043
DOI: 10.1016/j.cej.2025.168043

Nanozymes in IBD therapy: Rational design, catalytic mechanisms and targeted therapies delivery

Tingting Hu, Xiaoting Zhang, Mengmeng Dong, Fei Kong, Zhen Wang, Kaiqiang Li, Yu Cai, Xiangmin Tong and Ke Hao

Materials & Design, 2026, 262, 115475
DOI: 10.1016/j.matdes.2026.115475

Recent advancements for defect engineering in nanozymes

Dong Han, Xiaogang Li and Libo Zhang

Coordination Chemistry Reviews, 2026, 546, 217067
DOI: 10.1016/j.ccr.2025.217067

From monomodal to multimodal: The intelligent evolution of photoelectric nanozymes in food safety detection sensing

Jiaqi Song, Yue Xu, Yang Yang, Guang Zhang, Xinyu Xu, Jiawang Wang, Chunmin Ma and Na Zhang

Coordination Chemistry Reviews, 2026, 553, 217590
DOI: 10.1016/j.ccr.2026.217590

Bimetallic Gold--Platinum (AuPt) Nanozymes: Recent Advances in Synthesis and Applications for Food Safety Monitoring

Shipeng Gao, Xinhao Xu, Xueyun Zheng, Yang Zhang and Xinai Zhang

Foods, 2025, 14, 3229
DOI: 10.3390/foods14183229

Rational Design of Single‐Atom Nanozymes for Combination Cancer Immunotherapy

Hanchao Lin, Yonghui Gao, Le Zhu, Yu Guo, Lumin Zhang, Jiali Xie, Dongqin Yang, Jing Liu, Qiongzhu Dong and Zhiling Zhu

Adv Funct Materials, 2025, 35
DOI: 10.1002/adfm.202416563

Machine learning for nanozyme development in anti‐inflammatory applications

Yixin Yu, Zhicheng Zhu, Ziqi Zhang, Xinyu Liu, Yu Guo, Dehong Chen and Zhiling Zhu

Journal of Intelligent Medicine, 2024, 1, 91
DOI: 10.1002/jim4.13

A comprehensive review of nanozyme construction strategies and their applications in environmental analysis

Samar H. Elagamy, Reem H. Obaydo, Abdulsalam Ashkar and Hayam M. Lotfy

Sensors and Actuators Reports, 2025, 10, 100394
DOI: 10.1016/j.snr.2025.100394

Nanozymes in respiratory medicine: From ultra-sensitive diagnostics to intelligent therapeutics

Lianhua Liu, Xiaohua Yuan, Muhammad Idrees Khan, Qing Zhao, Imran Shakir, Xuping Sun and Fengming Luo

Coordination Chemistry Reviews, 2026, 551, 217387
DOI: 10.1016/j.ccr.2025.217387