Cross Reference Logo
Citations to this article as recorded by CrossRef and RSC Journals (166 citations).

From simple delivery to multimodal systems: the critical role of macromolecular platforms in bioorthogonal drug synthesis
Tieze van den Elsen and Kevin Neumann
J. Mater. Chem. B, 2025, 13, 8953
DOI: 10.1039/D5TB01111F

Dual-responsive PEG–lipid polyester nanoparticles for siRNA and vaccine delivery elicit anti-cancer immune responses by modulating tumor microenvironment
Zixu Liu, Linxuan Zhao, Yupeng Feng, Qingqing Wang, Nan Dong, Yu Zhang, Tian Yin, Haibing He, Xing Tang, Jingxin Gou and Li Yang
Biomater. Sci., 2023, 11, 6619
DOI: 10.1039/D3BM01265D

Recent advances in redox-responsive nanoparticles for combined cancer therapy
Yanjun Yang and Wen Sun
Nanoscale Adv., 2022, 4, 3504
DOI: 10.1039/D2NA00222A

Transformable nanodrugs for overcoming the biological barriers in the tumor environment during drug delivery
Xuejian Li, Zhenkun Huang, Zhihuan Liao, Aijie Liu and Shuaidong Huo
Nanoscale, 2023, 15, 8532
DOI: 10.1039/D2NR06621A

Development of “smart” drug delivery systems for chemo/PDT synergistic treatment
Miaomiao Yu, Ran Cao, Zhiyuan Ma and Meifang Zhu
J. Mater. Chem. B, 2023, 11, 1416
DOI: 10.1039/D2TB02248F

Polysaccharide-based C-dots and polysaccharide/C-dot nanocomposites: fabrication strategies and applications
Sina Bazazi, Seyedeh Parisa Hosseini, Esmaeil Hashemi, Bahaaldin Rashidzadeh, Yuqian Liu, Mohammad Reza Saeb, Huining Xiao and Farzad Seidi
Nanoscale, 2023, 15, 3630
DOI: 10.1039/D2NR07065K

In situ synthesis of bioorthogonally catalyzed drugs based on hydrogen-bonded organic frameworks for cancer therapy
Yan Wang, Luwen Zhang, Jiarui Qiao, Xianhao Wei, Tingyan Jiang, Junhe Ou and Maolin Pang
Inorg. Chem. Front., 2025, 12, 8626
DOI: 10.1039/D5QI01690H

Photo-induced specific intracellular release EGFR inhibitor from enzyme/ROS-dual sensitive nano-platforms for molecular targeted-photodynamic combinational therapy of non-small cell lung cancer
Man Zhang, Xuequan Zhang, Shengsheng Cai, Heng Mei, Yanmei He, Dennis Huang, Wenqiang Shi, Sai Li, Jun Cao and Bin He
J. Mater. Chem. B, 2020, 8, 7931
DOI: 10.1039/D0TB01053G

Biotransformation and biological fate of magnetic iron oxide nanoparticles for biomedical research and clinical applications
Carlos Jacinto, Yasir Javed, Gabriel Lavorato, Wilson A. Tarraga, Blessed Isaac C. Conde, Juan Manuel Orozco, Agustin S. Picco, Joel Garcia, Carlos Sato Baraldi Dias, Sonia Malik and Surender Kumar Sharma
Nanoscale Adv., 2025, 7, 2818
DOI: 10.1039/D5NA00195A

Recent advances in stimuli-responsive tailored nanogels for cancer therapy; from bench to personalized treatment
Prinsy Rana, Charan Singh, Ajeet Kaushik, Shakir Saleem and Arun Kumar
J. Mater. Chem. B, 2024, 12, 382
DOI: 10.1039/D3TB02650G

pH/redox sequentially responsive nanoparticles with size shrinkage properties achieve deep tumor penetration and reversal of multidrug resistance
Wanting Feng, Mingzhu Zong, Li Wan, Xiaojuan Yu and Weiyong Yu
Biomater. Sci., 2020, 8, 4767
DOI: 10.1039/D0BM00695E

Engineered nanomicelles targeting proliferation and angiogenesis inhibit tumour progression by impairing the synthesis of ceramide-1-phosphate
Poonam Yadav, Kajal Rana, Ruchira Chakraborty, Ali Khan, Devashish Mehta, Dolly Jain, Bharti Aggarwal, Somesh K. Jha, Ujjaini Dasgupta and Avinash Bajaj
Nanoscale, 2024, 16, 10350
DOI: 10.1039/D3NR04806C

Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration
Jiabao Sheng, Weisi Yuan, Mingjun Zhang, Ze Chen, Yanfei Qi, Yinan Zhao and Shubiao Zhang
J Nanobiotechnol, 2026, 24
DOI: 10.1186/s12951-026-04028-7

Innovations in targeted drug delivery: From nanotechnology to clinical applications
Akash Srivastava, Asad Ahmad, Shaiber Siddiqui and Anas Islam
Next Nanotechnology, 2026, 9, 100336
DOI: 10.1016/j.nxnano.2025.100336

Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer
Wenfeng Jia, Rui Liu, Yushan Wang, Chuan Hu, Wenqi Yu, Yang Zhou, Ling Wang, Mengjiao Zhang, Huile Gao and Xiang Gao
Acta Pharmaceutica Sinica B, 2022, 12, 3354
DOI: 10.1016/j.apsb.2022.03.010

Application of smart nanoparticles as a potential platform for effective colorectal cancer therapy
Sonia Iranpour, Ahmad Reza Bahrami, Amir Sh. Saljooghi and Maryam M. Matin
Coordination Chemistry Reviews, 2021, 442, 213949
DOI: 10.1016/j.ccr.2021.213949

Experimental study on preparation and anti-tumor efficiency of nanoparticles targeting M2 macrophages
Zheng Zeng, Yu Liu, Qinglian Wen, Yixian Li, Jing Yu, Qiang Xu, Wenwu Wan, Yu He, Chen Ma, Yan Huang, Helin Yang, Ou Jiang and Fuyu Li
Drug Delivery, 2021, 28, 943
DOI: 10.1080/10717544.2021.1921076

Lipid-coated ruthenium dendrimer conjugated with doxorubicin in anti-cancer drug delivery: Introducing protocols
Sylwia Michlewska, Zuzana Garaiova, Veronika Šubjakova, Marcin Hołota, Małgorzata Kubczak, Marika Grodzicka, Elżbieta Okła, Nikolaos Naziris, Łucja Balcerzak, Paula Ortega, Francisco Javier de la Mata, Tibor Hianik, Iveta Waczulikova, Maria Bryszewska and Maksim Ionov
Colloids and Surfaces B: Biointerfaces, 2023, 227, 113371
DOI: 10.1016/j.colsurfb.2023.113371

Repurposing Tamoxifen for Tumor Microenvironment Priming and Enhanced Tumor‐Targeted Drug Delivery
Ilaria Biancacci, Daniele De Santis, Elena Rama, Karina Benderski, Jeffrey Momoh, Robert Pohlberger, Diana Moeckel, Leonard Kaps, Cristianne J. F. Rijcken, Jai Prakash, Marielle Thewissen, Fabian Kiessling, Yang Shi, Quim Peña, Alexandros Marios Sofias, Lorena Consolino and Twan Lammers
Advanced Therapeutics, 2023, 6
DOI: 10.1002/adtp.202300098

Nucleic Acid-Gated Covalent Organic Frameworks for Cancer-Specific Imaging and Drug Release
Peng Gao, Xiaoying Shen, Xiaohan Liu, Yuanyuan Chen, Wei Pan, Na Li and Bo Tang
Anal. Chem., 2021, 93, 11751
DOI: 10.1021/acs.analchem.1c02105

Cubosomes in cancer drug delivery: A review
Ryan Varghese, Sahil Salvi, Purab Sood, Bhargavi Kulkarni and Dileep Kumar
Colloid and Interface Science Communications, 2022, 46, 100561
DOI: 10.1016/j.colcom.2021.100561

A vascularized tumors-on-a-chip model for studying tumor-angiogenesis interplay, heterogeneity and drug responses
Suyeon Shin, Yurim Choi, WonJun Jang, Batjargal Ulziituya, Giheon Ha, Raehui Kang, Soojin Park, Minseok Kim, Yu Shrike Zhang, Han-Jun Kim and Junmin Lee
Materials Today Bio, 2025, 32, 101741
DOI: 10.1016/j.mtbio.2025.101741

Nanobody-Based Drug Delivery: Emerging Strategies for Targeted Cancer Therapy
Nandan Ghosh, Nasim Sepay, Mohuya Paul and Jungkyun Im
IJN, 2026, Volume 21, 1
DOI: 10.2147/IJN.S584604

Pressure‐Gradient Counterwork of Dual‐Fuel Driven Nanocarriers in Abnormal Interstitial Fluids for Enhancing Drug Delivery Efficiency
Zhiwen Zheng, Xiaotong Zheng, Degang Kong, Kai Ding, Zhao Zhang, Run Zhong, Jing He and Shaobing Zhou
Small, 2023, 19
DOI: 10.1002/smll.202207252

Ionizable lipid nanoparticles with functionalized PEG-lipids increase retention in the tumor microenvironment
Matthew Jester, Rebecca M. Haley, Margaret M. Billingsley, Christian Figueroa-Espada, Ryann A. Joseph, Xuexiang Han and Michael J. Mitchell
Molecular Therapy Methods & Clinical Development, 2025, 33, 101457
DOI: 10.1016/j.omtm.2025.101457

Mannose modified co-loaded zoledronic liposomes deplete M2-tumor-associated macrophages to enhance anti-tumor effect of doxorubicin on TNBC
Yao Wendong, Xu Hengwu, Chen Yanhong, Xu Yingying, Zhou Feng, Wang Zeng and Cai Xinjun
Journal of Drug Delivery Science and Technology, 2022, 74, 103551
DOI: 10.1016/j.jddst.2022.103551

Nanotechnology Approaches for Prevention and Treatment of Chemotherapy‐Induced Neurotoxicity, Neuropathy, and Cardiomyopathy in Breast and Ovarian Cancer Survivors
Sarah Nevins, Callan D. McLoughlin, Alfredo Oliveros, Joshua B. Stein, Mohammad Abdur Rashid, Yannan Hou, Mi‐Hyeon Jang and Ki‐Bum Lee
Small, 2023
DOI: 10.1002/smll.202300744

Regulation of Interstitial Fluid Pressure for Improved Intratumor Drug Permeability and Nanozyme-Enhanced Chemocatalytic Therapy
Yaqian He, Mengxue Yang, Tao Wang, Liuyang Xu, Zhenhe Ma, Jian Mu, Desong Wang and Dawei Gao
ACS Sustainable Chem. Eng., 2022, 10, 8908
DOI: 10.1021/acssuschemeng.2c02129

Smart self-transforming nano-systems for overcoming biological barrier and enhancing tumor treatment efficacy
Jun Tao, Weiqing Ning, Wei Lu, Rui Wang, Hui Zhou, Hongru Zhang, Jiayi Xu, Shouju Wang, Zhaogang Teng and Lianhui Wang
Journal of Controlled Release, 2025, 380, 85
DOI: 10.1016/j.jconrel.2025.01.058

Human Solid Tumors and Clinical Relevance of The Enhanced Permeation and Retention Effect: A ‘Golden Gate’ for Nanomedicine in Preclinical Studies?
Poonam Gawali, Aishwarya Saraswat, Shruti Bhide, Sanjay Gupta and Ketan Patel
Nanomedicine (Lond.), 2023, 18, 169
DOI: 10.2217/nnm-2022-0257

Overcoming Biological Barriers With Block Copolymers-Based Self-Assembled Nanocarriers. Recent Advances in Delivery of Anticancer Therapeutics
Jazmin Torres, Namdev Dhas, Marcela Longhi and Mónica C. García
Front. Pharmacol., 2020, 11
DOI: 10.3389/fphar.2020.593197

Peptide-Conjugated Nano Delivery Systems for Therapy and Diagnosis of Cancer
Isha Gaurav, Xuehan Wang, Abhimanyu Thakur, Ashok Iyaswamy, Sudha Thakur, Xiaoyu Chen, Gaurav Kumar, Min Li and Zhijun Yang
Pharmaceutics, 2021, 13, 1433
DOI: 10.3390/pharmaceutics13091433

Shape Transformable Strategies for Drug Delivery
Wenfeng Jia, Yushan Wang, Rui Liu, Xiangrong Yu and Huile Gao
Adv Funct Materials, 2021, 31
DOI: 10.1002/adfm.202009765

pH/enzyme dual sensitive and nucleus-targeting dendrimer nanoparticles to enhance the antitumour activity of doxorubicin
Zi-Yan Wu, Jian-Min Shen, Hao Lang, Ting Yue and Chan Sun
Pharmaceutical Development and Technology, 2022, 27, 357
DOI: 10.1080/10837450.2022.2055569

The progress and perspective of nanoparticle-enabled tumor metastasis treatment
Wei Zhang, Fei Wang, Chuan Hu, Yang Zhou, Huile Gao and Jiang Hu
Acta Pharmaceutica Sinica B, 2020, 10, 2037
DOI: 10.1016/j.apsb.2020.07.013

Engineering nanotheranostic strategies for liver cancer
Lei Cao, Yu-Qin Zhu, Zhi-Xian Wu, Gao-Xiong Wang and Hong-Wei Cheng
WJGO, 2021, 13, 1213
DOI: 10.4251/wjgo.v13.i10.1213

Current perspectives and trend of nanomedicine in cancer: A review and bibliometric analysis
Zerong Pei, Shuting Chen, Liqin Ding, Jingbo Liu, Xinyi Cui, Fengyun Li and Feng Qiu
Journal of Controlled Release, 2022, 352, 211
DOI: 10.1016/j.jconrel.2022.10.023

Dual-Prodrug-Based Hyaluronic Acid Nanoplatform Provides Cascade-Boosted Drug Delivery for Oxidative Stress-Enhanced Chemotherapy
Junxian Zhang, Meigui Deng, Chang Xu, Danting Li, Xiaozhe Yan, Yuxuan Gu, Meihui Zhong, Hui Gao, Yingchun Liu, Jiqing Zhang, Xiongwei Qu and Jimin Zhang
ACS Appl. Mater. Interfaces, 2024, 16, 50459
DOI: 10.1021/acsami.4c11662

Unlocking the Molecular Targets in Non-Small-Cell Lung Cancer and a Nanomedicine-Based Remedy
Kangkan Sarma, Md Habban Akhter, Amnah Alalmaie, Irfan Ahmad, Mohd Nazam Ansari, Habibullah Khalilullah, Syeda Ayesha Farhana, Shalam M. Hussain and Adel M. Aljadaan
Crit Rev Ther Drug Carrier Syst, 2025, 42, 1
DOI: 10.1615/CritRevTherDrugCarrierSyst.2024053289

Combination Cancer Treatment: Using Engineered DNAzyme Molecular Machines for Dynamic Inter‐ and Intracellular Regulation
Ruo‐Can Qian, Ze‐Rui Zhou, Yuting Wu, Zhenglin Yang, Weijie Guo, Da‐Wei Li and Yi Lu
Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202210935

Combined cancer therapeutics—Tackling the complexity of the tumor microenvironment
Catarina Roma‐Rodrigues, Luís R. Raposo, Rúben Valente, Alexandra R. Fernandes and Pedro V. Baptista
WIREs Nanomed Nanobiotechnol, 2021, 13
DOI: 10.1002/wnan.1704

pH-responsive mesoporous Fe2O3–Au nanomedicine delivery system with magnetic targeting for cancer therapy
Jingxi Wang, Fengnian Zhu, Kun Li, Junwei Xu, Ping Li and Yubo Fan
Medicine in Novel Technology and Devices, 2022, 15, 100127
DOI: 10.1016/j.medntd.2022.100127

Alleviation of Tumor Invasion by the Development of Natural Polymer-based Low-risk Chemotherapeutic Systems – review on the Malignant Carcinoma Treatments
Vignesh Natarajan
CDD, 2025, 22, 1240
DOI: 10.2174/0115672018349688241008220007

Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis
Jie-Feng Zhao, Fei-Long Zou, Jin-Feng Zhu, Chao Huang, Fan-Qin Bu, Zheng-Ming Zhu and Rong-Fa Yuan
Front. Pharmacol., 2022, 13
DOI: 10.3389/fphar.2022.1025618

Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy
Wei Xu, Guoqiang Guan, Renye Yue, Zhe Dong, Lingling Lei, Heemin Kang and Guosheng Song
Chem. Rev., 2025, 125, 1897
DOI: 10.1021/acs.chemrev.4c00546

Application progress of nanomaterials in the treatment of prostate cancer
Xuewu Wu, Longtu Ma, Yang Zhang, Shuai Liu, Long Cheng, Chengyu You and Zhilong Dong
Annales Pharmaceutiques Françaises, 2025, 83, 1
DOI: 10.1016/j.pharma.2024.08.009

Manipulation of immune‒vascular crosstalk: new strategies towards cancer treatment
Yang Zhao, Xiangrong Yu and Jia Li
Acta Pharmaceutica Sinica B, 2020, 10, 2018
DOI: 10.1016/j.apsb.2020.09.014

High-drug-loading capacity of redox-activated biodegradable nanoplatform for active targeted delivery of chemotherapeutic drugs
Hai Zhang, Jianqin Yan, Heng Mei, Shengsheng Cai, Sai Li, Furong Cheng, Jun Cao and Bin He
Regenerative Biomaterials, 2020, 7, 359
DOI: 10.1093/rb/rbaa027

Phage therapy in oncology: opportunities for cancer prevention and treatment
Vivek K. Mutalik, Jamie L. Inman, Hang Chang, Adam Arkin and Jian-Hua Mao
Trends in Molecular Medicine, 2026
DOI: 10.1016/j.molmed.2026.02.001

Collagen-based biomaterials: recent advances on regulating cell migration and correlated biomedical applications
Qinghe Zhang, Minghuan Dou, Xinyi Su, Zelong Yu, Benmei Wei, Lian Zhu, Juntao Zhang and Haibo Wang
Collagen & Leather, 2025, 7
DOI: 10.1186/s42825-025-00197-7

Editorial of Special Issue on Tumor Microenvironment and Drug Delivery
Huile Gao, Zhiqing Pang and Wei He
Acta Pharmaceutica Sinica B, 2020, 10, 2016
DOI: 10.1016/j.apsb.2020.11.017

Nanocarrier cancer therapeutics with functional stimuli-responsive mechanisms
Neha Kaushik, Shweta B. Borkar, Sondavid K. Nandanwar, Pritam Kumar Panda, Eun Ha Choi and Nagendra Kumar Kaushik
J Nanobiotechnol, 2022, 20
DOI: 10.1186/s12951-022-01364-2

Glucose oxidase and metal catalysts combined tumor synergistic therapy: mechanism, advance and nanodelivery system
Yuhan Fu, Jialin Sun, Yanhong Wang and Weinan Li
J Nanobiotechnol, 2023, 21
DOI: 10.1186/s12951-023-02158-w

Supramolecular nanomedicines based on host–guest interactions of cyclodextrins
Fan Tong, Yang Zhou, Yanyan Xu, Yuxiu Chen, Natalia Yudintceva, Maxim Shevtsov and Huile Gao
Exploration, 2023, 3
DOI: 10.1002/EXP.20210111

Immune-based cancer therapies: mechanistic insights, clinical progress, and future directions
Mahalakshmi Devaraji and Binoy Varghese Cheriyan
J Egypt Natl Canc Inst, 2025, 37
DOI: 10.1186/s43046-025-00319-6

The design and straightforward synthesis of multifunctional DNA microgels for the improved targeted delivery of antitumor drugs
Fengyun Li, Jianing Gong, Taoran Shi, Xiaoliang Ren, Xinyi Cui, Li Xiao, Jingbo Liu and Feng Qiu
International Journal of Pharmaceutics, 2023, 643, 123242
DOI: 10.1016/j.ijpharm.2023.123242

Nano drug delivery system reconstruct tumour vasculature for the tumour vascular normalisation
Qiangwei Liang, Liyue Zhou, Yifan Li, Jinxia Liu and Yanhua Liu
Journal of Drug Targeting, 2022, 30, 119
DOI: 10.1080/1061186X.2021.1927056

Tumor‐Microenvironment‐Responsive Nanomedicine for Enhanced Cancer Immunotherapy
Shaojun Peng, Fengfeng Xiao, Meiwan Chen and Huile Gao
Advanced Science, 2022, 9
DOI: 10.1002/advs.202103836

Emerging trends in drug-device combination for advanced disease diagnosis and therapy
Zhe Liu, Yu Shi and Chenxi Liu
Nano Today, 2023, 50, 101853
DOI: 10.1016/j.nantod.2023.101853

Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment
Rui Liu, Cong Luo, Zhiqing Pang, Jinming Zhang, Shaobo Ruan, Meiying Wu, Lei Wang, Tao Sun, Nan Li, Liang Han, Jinjin Shi, Yuanyu Huang, Weisheng Guo, Shaojun Peng, Wenhu Zhou and Huile Gao
Chinese Chemical Letters, 2023, 34, 107518
DOI: 10.1016/j.cclet.2022.05.032

Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer
Khandoker Usran Ferdous, Mulu Z. Tesfay, Aleksandra Cios, Randal S. Shelton, Conner Hartupee, Alicja Urbaniak, Jean Christopher Chamcheu, Michail N. Mavros, Emmanouil Giorgakis, Bahaa Mustafa, Camila C. Simoes, Isabelle R. Miousse, Alexei G. Basnakian, Omeed Moaven, Steven R. Post, Martin J. Cannon, Thomas Kelly and Bolni Marius Nagalo
Biomedicines, 2024, 12, 1596
DOI: 10.3390/biomedicines12071596

Innovative nanoparticle-based therapies for pancreatic neuroendocrine tumours (PNETs): advances, challenges, and future directions
Olisaemeka Zikora Akunne, Lynda Ify Onyebuchukwu, Maduabuchi Gabriel Azu and Jennifer Chinaza Ogwurumba
Discov. Pharm. Sci., 2025, 1
DOI: 10.1007/s44395-025-00018-0

Engineering stimuli-responsive extracellular vesicles for enhanced anticancer therapeutics
Brian I. Molina Diaz, Pei Zhuang, Xiaoshu Pan, George Doctsch and Mei He
Current Opinion in Biomedical Engineering, 2026, 37, 100634
DOI: 10.1016/j.cobme.2025.100634

Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification
Heng Mei, Shengsheng Cai, Dennis Huang, Huile Gao, Jun Cao and Bin He
Bioactive Materials, 2022, 8, 220
DOI: 10.1016/j.bioactmat.2021.06.035

Breaking Glycolysis Barriers to Immunotherapy with Nanomedicines
Miya Zhang, Yanhong Ren, Jiaping Li, Jiaji Yu, Qianqi Li, Heng Zhao, Zheng Wang, Xiaoyuan Chen and Junjie Cheng
ACS Nano Med., 2026, 1, 149
DOI: 10.1021/acsnanomed.5c00042

GSH‐Responsive Shape‐Transformable Nanotheranostics for Dual‐Modal T1/T2 MRI‐Guided Enhanced PDT of Nasopharyngeal Carcinoma
Qianyu Yang, Gang Wu, Yefeng Yang, Yang Zhou, Jiali Song, Huile Gao and Weiyuan Huang
Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202402194

Silk Particles as Carriers of Therapeutic Molecules for Cancer Treatment
Anna Florczak, Inga Grzechowiak, Tomasz Deptuch, Kamil Kucharczyk, Alicja Kaminska and Hanna Dams-Kozlowska
Materials, 2020, 13, 4946
DOI: 10.3390/ma13214946

Aptamers as a new frontier in targeted cancer therapy
Yingying Li, Tatiana N. Zamay, Natalia A. Luzan, Evgeny A. Pryakhin, Elena V. Styazhkina, Liubov A. Osminkina, Olga S. Kolovskaya, Maya A. Dymova, Elena V. Kuligina, Vladimir A. Richter, Alena G. Bkhattachariia, Dmitry A. Bydanov, Alexander V. Galantsev, Ivan A. Vostrov, Zhenbao Liu, Galina S. Zamay, Anna S. Kichkailo and Xue-Qiang Wang
Advanced Drug Delivery Reviews, 2025, 226, 115692
DOI: 10.1016/j.addr.2025.115692

Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms
Yixuan Zi, Kaiyun Yang, Jianhua He, Zimei Wu, Jianping Liu and Wenli Zhang
Advanced Drug Delivery Reviews, 2022, 188, 114449
DOI: 10.1016/j.addr.2022.114449

Advances in the use of nanoparticles for specific cell-target delivery of anti-cancer agents
Ana Belen Diaz-Ruano, Eliana Gomez-Jimenez, Gloria Llamas-Jimenez, Arena Ramirez-Muñoz, Pablo Espejo-Hijano, Alfonso Rubio-Navarro and Manuel Picon-Ruiz
Life Sciences, 2025, 371, 123604
DOI: 10.1016/j.lfs.2025.123604

Targeted therapy of tumour microenvironment by gold nanoparticles as a new therapeutic approach
Negah Mahhengam, Kimia Kazemnezhad, Hendrik Setia Budi, Mohammad Javed Ansari, Dmitry Olegovich Bokov, Wanich Suksatan, Lakshmi Thangavelu and Homayoon Siahmansouri
Journal of Drug Targeting, 2022, 30, 494
DOI: 10.1080/1061186X.2022.2032095

Targeting autophagy in dysfunctional tumor vasculature
Qian Lin, Beichen Cai, Ruonan Ke, Xuejun Ni, Xiaofen Wan, Lu Chen, Tao Huang, Xiuying Shan and Biao Wang
iScience, 2025, 28, 114084
DOI: 10.1016/j.isci.2025.114084

Recent advances in zwitterionic nanoscale drug delivery systems to overcome biological barriers
Xumei Ouyang, Yu Liu, Ke Zheng, Zhiqing Pang and Shaojun Peng
Asian Journal of Pharmaceutical Sciences, 2024, 19, 100883
DOI: 10.1016/j.ajps.2023.100883

Nanotechnology-based immunotherapy, an emerging paradigm in breast cancer therapeutics
Pratik Chakraborty, Hiranmoy Bhattacharya and Saikat Dewanjee
International Immunopharmacology, 2025, 167, 115728
DOI: 10.1016/j.intimp.2025.115728

Nanoparticles in precision medicine for ovarian cancer: From chemotherapy to immunotherapy
Yuan Li, Yan Gao, Xi Zhang, Hongyan Guo and Huile Gao
International Journal of Pharmaceutics, 2020, 591, 119986
DOI: 10.1016/j.ijpharm.2020.119986

The progress and perspective of strategies to improve tumor penetration of nanomedicines
Jiang Hu, Xinwei Yuan, Fei Wang, Huile Gao, Xilin Liu and Wei Zhang
Chinese Chemical Letters, 2021, 32, 1341
DOI: 10.1016/j.cclet.2020.11.006

When imaging meets size-transformable nanosystems
Yang Zhou, Rui Liu, Maxim Shevtsov and Huile Gao
Advanced Drug Delivery Reviews, 2022, 183, 114176
DOI: 10.1016/j.addr.2022.114176

Construction of carboxymethyl chitosan-based nanoparticles of hypoxia response for co-loading doxorubicin and tanshinone IIA
Mengli Lu, Li Ma, Juncan Li, Jie Li, Miao Tong, Fuli Dai, Feiyu Song, Xueqiong Zhang and Tong Qiu
International Journal of Biological Macromolecules, 2023, 244, 125362
DOI: 10.1016/j.ijbiomac.2023.125362

Injectable rapidly dissolving needle-type gelatin implant capable of delivering high concentrations of H2O2 through intratumoral injection
Sewon Park, Jungyu Kim and Changkyu Lee
Biomedicine & Pharmacotherapy, 2022, 156, 113910
DOI: 10.1016/j.biopha.2022.113910

Strategies to Overcome the Barrier of Ischemic Microenvironment in Cell Therapy of Cardiovascular Disease
Rouven Berndt, Martin Albrecht and René Rusch
IJMS, 2021, 22, 2312
DOI: 10.3390/ijms22052312

Advances of nanomedicines in breast cancer metastasis treatment targeting different metastatic stages
Wenqi Yu, Chuan Hu and Huile Gao
Advanced Drug Delivery Reviews, 2021, 178, 113909
DOI: 10.1016/j.addr.2021.113909

Emerging Approaches in Glioblastoma Treatment: Modulating the Extracellular Matrix Through Nanotechnology
Miguel Horta, Paula Soares, Catarina Leite Pereira and Raquel T. Lima
Pharmaceutics, 2025, 17, 142
DOI: 10.3390/pharmaceutics17020142

Exploring lung cancer microenvironment: pathways and nanoparticle-based therapies
Arunabh Arandhara, Pallabi Bhuyan and Bhrigu Kumar Das
Discov Onc, 2025, 16
DOI: 10.1007/s12672-025-01902-y

Detachable Dual-Targeting Nanoparticles for Improving the Antitumor Effect by Extracellular Matrix Depletion
Songchao Duan, Fangfang Sun, Pan Qiao, Zhihui Zhu, Meilin Geng, Xiaobao Gong, Ying Li and Hanchun Yao
ACS Biomater. Sci. Eng., 2023, 9, 1437
DOI: 10.1021/acsbiomaterials.2c01179

Construction of Core-Cross-Linked Polymer Micelles with High Biocompatibility and Stability for pH/Reduction Controllable Drug Delivery
Yehong Liu, Miaoxin Chen, Gaoyang Li, Shouhong Xu and Honglai Liu
Langmuir, 2023, 39, 12671
DOI: 10.1021/acs.langmuir.3c01341

Tumor microenvironment-responsive dynamic inorganic nanoassemblies for cancer imaging and treatment
Yu Yang, Hao Wu, Bo Liu and Zhuang Liu
Advanced Drug Delivery Reviews, 2021, 179, 114004
DOI: 10.1016/j.addr.2021.114004

Versatile and Robust Method for Antibody Conjugation to Nanoparticles with High Targeting Efficiency
Indra Van Zundert, Maria Bravo, Olivier Deschaume, Pierre Cybulski, Carmen Bartic, Johan Hofkens, Hiroshi Uji-i, Beatrice Fortuni and Susana Rocha
Pharmaceutics, 2021, 13, 2153
DOI: 10.3390/pharmaceutics13122153

Graphene Quantum Dots from Natural Carbon Sources for Drug and Gene Delivery in Cancer Treatment
Henrry M. Osorio, Fabián Castillo-Solís, Selena Y. Barragán, Cristina Rodríguez-Pólit and Rebeca Gonzalez-Pastor
IJMS, 2024, 25, 10539
DOI: 10.3390/ijms251910539

Probability of Tumor Lysis Syndrome in Electrochemotherapy of Large Solid Tumors: A Pilot Study
Amiradel Larijani, Seyyed Mojtaba Yazdanparast, Farshid Rostami Pouria, Navid Manoochehri, Mahdis Bayat, Sama Mansouri, Nasim Sharghi, Sepideh Mansouri, Omid Nabavian, Fereidoon Memari, Habibollah Mahmoodzadeh, Seyed Rouhollah Miri, Mohammad Abdolahad and Ricardo Santiago Gomez
European Journal of Cancer Care, 2025, 2025
DOI: 10.1155/ecc/8152344

Adjuvant Novel Nanocarrier-Based Targeted Therapy for Lung Cancer
Kangkan Sarma, Md Habban Akther, Irfan Ahmad, Obaid Afzal, Abdulmalik S. A. Altamimi, Manal A. Alossaimi, Mariusz Jaremko, Abdul-Hamid Emwas and Preety Gautam
Molecules, 2024, 29, 1076
DOI: 10.3390/molecules29051076

CAR-T Cells in the Treatment of Ovarian Cancer: A Promising Cell Therapy
Xi-Wen Zhang, Yi-Shi Wu, Tian-Min Xu and Man-Hua Cui
Biomolecules, 2023, 13, 465
DOI: 10.3390/biom13030465

Microenvironment-responsive size-adaptive nanoparticles: hyaluronidase/acid/NIR light activation for deep-penetration trimodal therapy
Hao Wu, Hongping Li, Li Li, Yungchang Chen, Hongping Yang, Chongxiu Shi, Wenhao Li, Li Ye, Liming Zhu, Gang He, Suling Luo, Jing Tao, Ling Mei and Xue Shen
Materials Today Bio, 2025, 35, 102384
DOI: 10.1016/j.mtbio.2025.102384

Respiratory emerging viruses and drug resistance in lung cancer: challenges and new perspectives in treatment
Qiang Wu, Wen Li, Hongli Liu, Yinyin Xue, Kaili Huang, Hossein Pourghadamyari and Zhenkun Liu
Molecular Aspects of Medicine, 2025, 104, 101383
DOI: 10.1016/j.mam.2025.101383

Smart hypoxia-responsive transformable and charge-reversible nanoparticles for the deep penetration and tumor microenvironment modulation of pancreatic cancer
Hongyi Chen, Qin Guo, Yongchao Chu, Chao Li, Yiwen Zhang, Peixin Liu, Zhenhao Zhao, Yu Wang, Yifan Luo, Zheng Zhou, Tongyu Zhang, Haolin Song, Xuwen Li, Chufeng Li, Boyu Su, Haoyu You, Tao Sun and Chen Jiang
Biomaterials, 2022, 287, 121599
DOI: 10.1016/j.biomaterials.2022.121599

Advanced Drug Delivery Strategies for Overcoming Biological Barriers: Tumor Microenvironment and Blood–Brain Barrier
Yicong Lei, Tingyu Xiao, Xin Hu and Huaqing Lin
Drugs R D, 2026
DOI: 10.1007/s40268-026-00538-9

Cathepsin B-Responsive Nanocarriers: Silica and Liposomes for Precision Cancer Therapy
Sumiya Iqbal, Niklas Schlensog, Valerie Tan Shu Li, Shaista Ilyas and Sanjay Mathur
ACS Appl. Bio Mater., 2026
DOI: 10.1021/acsabm.5c02219

Graphene oxide nanosheets enhancing the photothermal response of a cellular barrier exposed to near infrared light
Chao Lu, Howyn Tang and Jin Zhang
Can J Chem Eng, 2024, 102, 2151
DOI: 10.1002/cjce.25186

Advanced diagnostic and therapeutic strategies in nanotechnology for lung cancer
Yujuan Duan, Chen Shen, Yinan Zhang and Yao Luo
Front. Oncol., 2022, 12
DOI: 10.3389/fonc.2022.1031000

Reduction/pH-responsive disassemblable MOF-microbial nanohybrid for targeted tumor penetration and synergistic therapy
Xuemei Zeng, Pengjie Li, Shuangqian Yan and Bi-Feng Liu
Chemical Engineering Journal, 2023, 452, 139517
DOI: 10.1016/j.cej.2022.139517

Stimuli‐Responsive Aptamer‐Drug Conjugates for Targeted Drug Delivery and Controlled Drug Release
Shanshan Zhu, Huan Gao, Wenyuan Li, Xiaocong He, Panpan Jiang, Feng Xu, Guorui Jin and Hui Guo
Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202401020

Role and mechanisms of exercise therapy in enhancing drug treatment for glioma: a review
Guanghui Wu, Yisheng Chen, Chong Chen, Jianling Liu, Qiaowu Wu, Yazhen Zhang, Runqiong Chen, Jianzhong Xiao, Yusheng Su, Haojun Shi, Chunsheng Yu, Miao Wang, Yifan Ouyang, Airong Jiang, Zhengzhou Chen, Xiao Ye, Chengwan Shen, Aikebaier Reheman, Xianjun Li, Ming Liu and Jiancheng Shen
Front. Immunol., 2025, 16
DOI: 10.3389/fimmu.2025.1576283

3D printable customized drug delivery system for the vaginal delivery of therapeutics: Unlocking potential prospects for women care
Suraj Kumar, Rishabha Malviya and Sathvik Belagodu Sridhar
Annals of 3D Printed Medicine, 2024, 16, 100177
DOI: 10.1016/j.stlm.2024.100177

Indocyanine green potentiated paclitaxel nanoprodrugs for imaging and chemotherapy
Xiujuan Xiang, Xuan Feng, Shaojin Lu, Bowen Jiang, Dengyuan Hao, Qing Pei, Zhigang Xie and Xiabin Jing
Exploration, 2022, 2
DOI: 10.1002/EXP.20220008

Combination Cancer Treatment: Using Engineered DNAzyme Molecular Machines for Dynamic Inter‐ and Intracellular Regulation
Ruo‐Can Qian, Ze‐Rui Zhou, Yuting Wu, Zhenglin Yang, Weijie Guo, Da‐Wei Li and Yi Lu
Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202210935

Recent advances in nano/micro systems for improved circulation stability, enhanced tumor targeting, penetration, and intracellular drug delivery: a review
Wei-Jen Chan and Huatian Li
Biomed. Phys. Eng. Express, 2024, 10, 022001
DOI: 10.1088/2057-1976/ad14f0

Progress and challenges in the translation of cancer nanomedicines
Fan Tong, Yufan Wang and Huile Gao
Current Opinion in Biotechnology, 2024, 85, 103045
DOI: 10.1016/j.copbio.2023.103045

Recent Advances in Cancer Immunotherapy Delivery Modalities
Palaniyandi Muthukutty, Hyun Woo, Murali Ragothaman and So Yoo
Pharmaceutics, 2023, 15, 504
DOI: 10.3390/pharmaceutics15020504

Redox-sensitive irinotecan liposomes with active ultra-high loading and enhanced intracellular drug release
Tao Wang, Wei He, Yawei Du, Ji Wang and Xinsong Li
Colloids and Surfaces B: Biointerfaces, 2021, 206, 111967
DOI: 10.1016/j.colsurfb.2021.111967

ROS-triggered nanoinducer based on dermatan sulfate enhances immunogenic cell death in melanoma
Qixiong Zhang, Shanshan Li, Jiandong Ren, Xia He, Houkui Shi, Fuzhong Zhang, Hui Li and Rongsheng Tong
Journal of Controlled Release, 2022, 348, 22
DOI: 10.1016/j.jconrel.2022.04.026

Charge‐Reversible Nanoparticles: Advanced Delivery Systems for Therapy and Diagnosis
Florina Veider, Eva Sanchez Armengol and Andreas Bernkop‐Schnürch
Small, 2024, 20
DOI: 10.1002/smll.202304713

The role of acoustofluidics and microbubble dynamics for therapeutic applications and drug delivery
S. I. Kaykanat and A. K. Uguz
Biomicrofluidics, 2023, 17
DOI: 10.1063/5.0130769

Humidity‐Gated Moisture‐Electric Therapy via Dual‐Modal Eelectrostimulation for Adaptive Bioelectronic Interventions
Jiacheng Shi, Mingjie Kuang, Xinting Liu, Mengbin Ding, Yuhan Zhang, Xue Yuan, Ruiyan Li, Yijing Zhang, Yiwen Yang, Li Wang, Yong Kang and Xiaoyuan Ji
Advanced Materials, 2026, 38
DOI: 10.1002/adma.202509865

Nitric Oxide‐Based Nanomedicines for Conquering TME Fortress: Say “NO” to Insufficient Tumor Treatment
Yuting Xiang, Qiaohui Chen, Yayun Nan, Min Liu, Zuoxiu Xiao, Yuqi Yang, Jinping Zhang, Xiaohong Ying, Xingyu Long, Shuya Wang, Jian Sun, Qiong Huang and Kelong Ai
Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202312092

Insights into Infusion-Based Targeted Drug Delivery in the Brain: Perspectives, Challenges and Opportunities
Asad Jamal, Tian Yuan, Stefano Galvan, Antonella Castellano, Marco Riva, Riccardo Secoli, Andrea Falini, Lorenzo Bello, Ferdinando Rodriguez y Baena and Daniele Dini
IJMS, 2022, 23, 3139
DOI: 10.3390/ijms23063139

Light-responsive nanomedicine for cancer immunotherapy
Weirong Kang, Yuwei Liu and Weiping Wang
Acta Pharmaceutica Sinica B, 2023, 13, 2346
DOI: 10.1016/j.apsb.2023.05.016

Novel strategies for modulating the gut microbiome for cancer therapy
Young Seok Cho, Kai Han, Jin Xu and James J. Moon
Advanced Drug Delivery Reviews, 2024, 210, 115332
DOI: 10.1016/j.addr.2024.115332

One-pot self-assembly fabrication of chitosan coated hollow sphere for pH/ glutathione dual responsive drug delivery
Jiagen Li, Yaqi Li, Zhanqiong Zhong, Xiaohong Fu and Zhonghui Li
Colloids and Surfaces B: Biointerfaces, 2022, 218, 112773
DOI: 10.1016/j.colsurfb.2022.112773

Leveraging vascular normalization via eNOS activation to enhance the efficacy of PD-L1 blockade
Yang Zhou and Huile Gao
Acta Pharmaceutica Sinica B, 2026, 16, 1793
DOI: 10.1016/j.apsb.2026.02.025

A pH-sensitive supramolecular nanosystem with chlorin e6 and triptolide co-delivery for chemo-photodynamic combination therapy
Yihan Wu, Jingjing Li, Xuemei Zhong, Jinfeng Shi, Yanfen Cheng, Chenglin He, Jiaxin Li, Liang Zou, Chaomei Fu, Meiwan Chen, Jinming Zhang and Huile Gao
Asian Journal of Pharmaceutical Sciences, 2022, 17, 206
DOI: 10.1016/j.ajps.2021.12.003

Nano-drug delivery strategies affecting cancer-associated fibroblasts to reduce tumor metastasis
Linghui Zou, Peng Xian, Qing Pu, Yangjie Song, Shuting Ni, Lei Chen and Kaili Hu
Acta Pharmaceutica Sinica B, 2025, 15, 1841
DOI: 10.1016/j.apsb.2025.02.040

Vascular and extracellular matrix remodeling by physical approaches to improve drug delivery at the tumor site
Sara Gouarderes, Anne-Françoise Mingotaud, Patricia Vicendo and Laure Gibot
Expert Opinion on Drug Delivery, 2020, 17, 1703
DOI: 10.1080/17425247.2020.1814735

Artificial tumor microenvironment regulated by first hemorrhage for enhanced tumor targeting and then occlusion for synergistic bioactivation of hypoxia-sensitive platesomes
Wenhui Tao, Dongyang Zhao, Guanting Li, Lingxiao Li, Songhao Li, Hao Ye, Chutong Tian, Yutong Lu, Shuying Li, Yinghua Sun, Zhonggui He and Jin Sun
Acta Pharmaceutica Sinica B, 2022, 12, 1487
DOI: 10.1016/j.apsb.2021.08.010

Cubosomes and its Pharmaceutical Application in Treatment of Cancer
Deshmukh Shradha Suresh, Dr. Anil P. Dewani and Prof (Dr.) A. V. Chandewar
IJARSCT, 2023, 451
DOI: 10.48175/IJARSCT-8628

Emerging 3D printing technologies for drug delivery devices: Current status and future perspective
Jiawei Wang, Yu Zhang, Niloofar Heshmati Aghda, Amit Raviraj Pillai, Rishi Thakkar, Ali Nokhodchi and Mohammed Maniruzzaman
Advanced Drug Delivery Reviews, 2021, 174, 294
DOI: 10.1016/j.addr.2021.04.019

Lipid nanoparticle–mediated in vivo generation of panCAR immune cells for solid tumor immunotherapy
Qimeng Yin, Xue Liang, Chenchen Zhang, Yuerong Bai, Jiahao Li, Feng Qian and Min Qiu
Proc. Natl. Acad. Sci. U.S.A., 2026, 123
DOI: 10.1073/pnas.2509698123

Tumor extracellular matrix modulating strategies for enhanced antitumor therapy of nanomedicines
Meng Li, Yijing Zhang, Qin Zhang and Jingchao Li
Materials Today Bio, 2022, 16, 100364
DOI: 10.1016/j.mtbio.2022.100364

Combination Therapy of Lox Inhibitor and Stimuli‐Responsive Drug for Mechanochemically Synergistic Breast Cancer Treatment
Shanshan Zhu, Tian Zhang, Huan Gao, Guorui Jin, Jin Yang, Xiaocong He, Hui Guo and Feng Xu
Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202300103

Transfection Efficacy and Cellular Uptake of Lipid-Modified Polyethyleneimine Derivatives for Anionic Nanoparticles as Gene Delivery Vectors
Amarnath Praphakar Rajendran, Oluwanifemi Ogundana, Luis Carlos Morales, Daniel Nisakar Meenakshi Sundaram, Cezary Kucharski, Remant KC and Hasan Uludağ
ACS Appl. Bio Mater., 2023, 6, 1105
DOI: 10.1021/acsabm.2c00978

Hyperthermia-triggered biomimetic bubble nanomachines
Junbin Gao, Hanfeng Qin, Fei Wang, Lu Liu, Hao Tian, Hong Wang, Shuanghu Wang, Juanfeng Ou, Yicheng Ye, Fei Peng and Yingfeng Tu
Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-40474-9

Shape Dependent Therapeutic Potential of Nanoparticulate System: Advance Approach for Drug Delivery
Shristy Verma, Rishabha Malviya, Saurabh Srivastava, Irfan Ahmad, Bhupinder Singh, Rasha Almontasheri and Prerna Uniyal
CPD, 2024, 30, 2606
DOI: 10.2174/0113816128314618240628110218

Photodynamic immunotherapy with checkpoint inhibitor-loaded nanogels: A synergistic frontier in cancer nanomedicine
Yue Song
Nanomedicine: Nanotechnology, Biology and Medicine, 2026, 73, 102915
DOI: 10.1016/j.nano.2026.102915

Acid‐Responsive Aggregated Gold Nanoparticles for Radiosensitization and Synergistic Chemoradiotherapy in the Treatment of Esophageal Cancer
Siyuan Luan, Rou Xie, Yushang Yang, Xin Xiao, Jianfeng Zhou, Xiaokun Li, Pinhao Fang, Xiaoxi Zeng, Xiangrong Yu, Meiwan Chen, Huile Gao and Yong Yuan
Small, 2022, 18
DOI: 10.1002/smll.202200115

ROS-responsive biomimetic nanoparticles for potential application in targeted anti-atherosclerosis
Dan Tang, Yi Wang, Andy Wijaya, Boyan Liu, Ali Maruf, Jinxuan Wang, Jianxiong Xu, Xiaoling Liao, Wei Wu and Guixue Wang
Regenerative Biomaterials, 2021, 8
DOI: 10.1093/rb/rbab033

The Evolution and Recent Trends in Acoustic Targeting of Encapsulated Drugs to Solid Tumors: Strategies beyond Sonoporation
Arvin Honari and Shashank R. Sirsi
Pharmaceutics, 2023, 15, 1705
DOI: 10.3390/pharmaceutics15061705

Innovative CAR-T Cell Therapy for Solid Tumor; Current Duel between CAR-T Spear and Tumor Shield
Yuna Jo, Laraib Amir Ali, Ju A Shim, Byung Ha Lee and Changwan Hong
Cancers, 2020, 12, 2087
DOI: 10.3390/cancers12082087

Murine Breast Cancer Radiosensitization Using Oxygen Microbubbles and Metformin: Vessels Are the Key
Agnieszka Drzał, Gabriela Dziurman, Paweł Hoła, Jakub Lechowski, Anthony Delalande, Jan Swakoń, Chantal Pichon and Martyna Elas
IJMS, 2023, 24, 12156
DOI: 10.3390/ijms241512156

Treatment of lung diseases via nanoparticles and nanorobots: Are these viable alternatives to overcome current treatments?
Meekha George, Rabah Boukherroub, Amitav Sanyal and Sabine Szunerits
Materials Today Bio, 2025, 31, 101616
DOI: 10.1016/j.mtbio.2025.101616

Engineered Magnetobacterial Microrobots with Tunable Self-Mineralization for Precise Imaging-Guided Photothermal Therapy
Hui Ran, Lishan Zhang, Yicheng Ye, Ning Zhong, Yuanyuan Wang, Bingquan Huang, Yuejun Jiang, Xue Yang, Qiuyun Wei, Hao Tian, Fei Peng and Yingfeng Tu
ACS Nano, 2026, 20, 10466
DOI: 10.1021/acsnano.5c19758

Furin-instructed aggregated gold nanoparticles for re-educating tumor associated macrophages and overcoming breast cancer chemoresistance
Rou Xie, Shaobo Ruan, Jiaqi Liu, Lin Qin, Chuanyao Yang, Fan Tong, Ting Lei, Maxim Shevtsov, Huile Gao and Yi Qin
Biomaterials, 2021, 275, 120891
DOI: 10.1016/j.biomaterials.2021.120891

Multi-scale computational modeling towards efficacy in radiopharmaceutical therapies while minimizing side effects: Modeling of amino acid infusion
Aryan Golzaryan, Mohammad Souri, Farshad M. Kashkooli, Arman Rahmim, M. Soltani and James Gallo,
PLoS Comput Biol, 2025, 21, e1013247
DOI: 10.1371/journal.pcbi.1013247

Experimental study on synergistic pulses improving the tumor microenvironment and assisting immunotherapy
Shoulong Dong, Zongnan Liu, Zetong Wang, Xinyu Peng, Qinyu Huang, Haobo Yang, Yuan Lei and Chenguo Yao
Front. Immunol., 2026, 17
DOI: 10.3389/fimmu.2026.1751463

Revolutionizing Cancer Immunotherapy: Emerging Nanotechnology-Driven Drug Delivery Systems for Enhanced Therapeutic Efficacy
Panneerselvam Theivendren, Selvaraj Kunjiappan, Parasuraman Pavadai, Kaveena Ravi, Anusuya Murugavel, Avinash Dayalan and A. Santhana Krishna Kumar
ACS Meas. Sci. Au, 2025, 5, 31
DOI: 10.1021/acsmeasuresciau.4c00062

Cargo‐Templated Crosslinked Polymer Nanocapsules and Their Biomedical Applications
Yu Zhao, Qiushi Li, Jingshan Chai and Yang Liu
Advanced NanoBiomed Research, 2021, 1
DOI: 10.1002/anbr.202000078

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors
Mukaddes Izci, Christy Maksoudian, Bella B. Manshian and Stefaan J. Soenen
Chem. Rev., 2021, 121, 1746
DOI: 10.1021/acs.chemrev.0c00779

Glucose-Fueled Gated Nanomotors: Enhancing In Vivo Anticancer Efficacy via Deep Drug Penetration into Tumors
Andrea Escudero, Francisco J. Hicke, Elena Lucena-Sánchez, Sandra Pradana-López, Juan José Esteve-Moreno, Víctor Sanz-Álvarez, Iris Garrido-Cano, Sandra Torres-Ruiz, Juan Miguel Cejalvo, Alba García-Fernández, Paula Díez and Ramón Martínez-Máñez
ACS Nano, 2025, 19, 20932
DOI: 10.1021/acsnano.5c03799

Intelligent Size-Changeable Nanoparticles for Enhanced Tumor Accumulation and Deep Penetration
Wenqi Yu, Chuan Hu and Huile Gao
ACS Appl. Bio Mater., 2020, 3, 5455
DOI: 10.1021/acsabm.0c00917

Advanced nanoplatforms for oxaliplatin-based breast cancer therapy: targeted delivery, stimuli-responsive design, and translational challenges
Arghya Paria, Md Ali Mujtaba, Sonam M. Gandhi, Vipin Saini, Devesh U. Kapoor and Dikshitkumar Modi
Naunyn-Schmiedeberg's Arch Pharmacol, 2026
DOI: 10.1007/s00210-026-05161-8

In-situ activation of CuAl-LDH nanosheets to catalyze bioorthogonal chemistry in vivo in tumor microenvironment for precise chemotherapy and chemodynamic therapy
Sa Wang, Shuqing Yang, Zhuolin Cui, Xueyan Liu, Yu Yang, Tao Wang, Wenjuan Ma, Yubin Zhou, Ruizheng Liang, Dan Yan and Huizhi Chen
Chemical Engineering Journal, 2023, 457, 141186
DOI: 10.1016/j.cej.2022.141186

Tumor Therapy Strategies Based on Microenvironment‐Specific Responsive Nanomaterials
Zhaocong Zhang, Chengwen Ding, Tiedong Sun, Lei Wang and Chunxia Chen
Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202300153

Lipid-polymer hybrid nanoparticles: a cutting-edge frontier in breast cancer treatment strategies
Marwa Alawi, Ayah R Hilles, Mohit Kumar, Mohd Danish Ansari and Syed Mahmood
Nanomedicine, 2025, 20, 1775
DOI: 10.1080/17435889.2025.2523730

Programmable Release of Chemotherapeutics from Ferrocene‐Based Injectable Hydrogels Slows Melanoma Growth
Rebecca Rothe, Yong Xu, Johanna Wodtke, Florian Brandt, Sebastian Meister, Markus Laube, Pier‐Luigi Lollini, Yixin Zhang, Jens Pietzsch and Sandra Hauser
Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202400265

The CTCF/LncRNA‐PACERR complex recruits E1A binding protein p300 to induce pro‐tumour macrophages in pancreatic ductal adenocarcinoma via directly regulating PTGS2 expression
Yihao Liu, Xuelong Wang, Youwei Zhu, Yizhi Cao, Liwen Wang, Fanlu Li, Yu Zhang, Ying Li, Zhiqiang Zhang, Jiaxin Luo, Xiaxing Deng, Chenghong Peng, Gang Wei, Hao Chen and Baiyong Shen
Clinical & Translational Med, 2022, 12
DOI: 10.1002/ctm2.654

Advances in targeted drug delivery systems for cancer treatment: Current trends and future prospects
Hafeez Ullah Khan, Nadeem Raza, Safirah Maheen, Hanzala Abbas, Mostafa E. Salem, Ikramullah Khan, Manal Naseem and Syed Salman Shafqat
Journal of Drug Delivery Science and Technology, 2025, 113, 107402
DOI: 10.1016/j.jddst.2025.107402

Surfactant-mediated carriers for gemcitabine: New insights and future prospects
Amarah Sultan Rana, Nadeem Raza, Mehwish Abid and Muhammad Faizan Nazar
Surfaces and Interfaces, 2025, 77, 108066
DOI: 10.1016/j.surfin.2025.108066

Cancer bone metastases and nanotechnology-based treatment strategies
Zhaofeng Li, Wei Zhang, Zhong Zhang, Huile Gao and Yi Qin
Expert Opinion on Drug Delivery, 2022, 19, 1217
DOI: 10.1080/17425247.2022.2093856

Engineering approaches for innate immune-mediated tumor microenvironment remodeling
G.I. Kane, C.F. Lusi, M.L. Brassil and P.U. Atukorale
Immuno-Oncology and Technology, 2024, 21, 100406
DOI: 10.1016/j.iotech.2023.100406

Recent advances in drug delivery systems for enhancing drug penetration into tumors
Bin He, Xin Sui, Bing Yu, Song Wang, Youqing Shen and Hailin Cong
Drug Delivery, 2020, 27, 1474
DOI: 10.1080/10717544.2020.1831106

N-Isopropylacrylamide-modified polyethylenimine-mediated miR-29a delivery to inhibit the proliferation and migration of lung cancer cells
Jiakai Xing, Jiaxin Jia, Xiaofeng Cong, Ziling Liu and Quanshun Li
Colloids and Surfaces B: Biointerfaces, 2021, 198, 111463
DOI: 10.1016/j.colsurfb.2020.111463

Effect of tumor heterogeneity on enhancing drug delivery to vascularized tumors using thermo-sensitive liposomes triggered by hyperthermia: A multi-scale and multi-physics computational model
Masoud H.H. Tehrani, Farshad Moradi Kashkooli and M. Soltani
Computers in Biology and Medicine, 2024, 170, 108050
DOI: 10.1016/j.compbiomed.2024.108050

Remodeling Tumor Microenvironment by Multifunctional Nanoassemblies for Enhanced Photodynamic Cancer Therapy
Chen Liang, Xinglin Zhang, Mengsu Yang, Wenjun Wang, Peng Chen and Xiaochen Dong
ACS Materials Lett., 2020, 2, 1268
DOI: 10.1021/acsmaterialslett.0c00259

Construction and applications of DNA-based nanomaterials in cancer therapy
Hedong Qi, Yuwei Xu, Pin Hu, Chi Yao and Dayong Yang
Chinese Chemical Letters, 2022, 33, 1131
DOI: 10.1016/j.cclet.2021.09.026

Tumor versus Tumor Cell Targeting in Metal-Based Nanoparticles for Cancer Theranostics
Jesús David Urbano-Gámez, Cinzia Guzzi, Manuel Bernal, Juan Solivera, Iñigo Martínez-Zubiaurre, Carlos Caro and María Luisa García-Martín
IJMS, 2024, 25, 5213
DOI: 10.3390/ijms25105213

Sequentially responsive size reduction and drug release of core-satellite nanoparticles to enhance tumor penetration and effective tumor suppression
Jiayi Sun, Jingyang Li, Xi Li, Lu Yang, Yitong Liu, Huile Gao and Li Xiang
Chinese Chemical Letters, 2023, 34, 107891
DOI: 10.1016/j.cclet.2022.107891

Anticancer lipid-based drug delivery systems: Basic knowledge and recent applications
Mohamed M. Shehata
Nano TransMed, 2024, 3, 100054
DOI: 10.1016/j.ntm.2024.100054

An update on dual targeting strategy for cancer treatment
Yasamin Davatgaran Taghipour, Amir Zarebkohan, Roya Salehi, Fariborz Rahimi, Vladimir P. Torchilin, Michael R. Hamblin and Alexander Seifalian
Journal of Controlled Release, 2022, 349, 67
DOI: 10.1016/j.jconrel.2022.06.044

Membrane Fusion Liposomes Deliver Antifibrotic and Chemotherapeutic Drugs Sequentially to Enhance Tumor Treatment Efficacy by Reshaping Tumor Microenvironment
Nan Jia, Qi Wang, Wenpan Li, Dawei Chen and Haiyang Hu
Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202400219