6′-O-Caffeoylarbutin from Que Zui tea ameliorates acetaminophen-induced liver injuryviaenhancing antioxidant ability and regulating the PI3K signaling pathway

Yong-Peng Wang, Yu-Dan Wang, Ya-Ping Liu, Jian-Xin Cao, Mei-Lian Yang, Yi-Fen Wang, Afsar Khan, Tian-Rui Zhao and Gui-Guang Cheng

Food Funct., 2022, 13, 5299
DOI: 10.1039/D2FO00507G

E Se tea alleviates acetaminophen-induced liver injury by activating the Nrf2 signaling pathway

Jinke Zhang, Mengcheng Li, Tianrui Zhao, Jianxin Cao, Yaping Liu, Yongpeng Wang, Yifen Wang and Guiguang Cheng

Food Funct., 2022, 13, 7240
DOI: 10.1039/D1FO02491D

l-Theanine mediates the p38MAPK signaling pathway to alleviate heat-induced oxidative stress and inflammation in mice

Kehong Liu, Enshuo Liu, Ling Lin, Yuan Hu, Yong Yuan and Wenjun Xiao

Food Funct., 2022, 13, 2120
DOI: 10.1039/D1FO03077A

Walnut protein hydrolysates ameliorate alcohol-induced cognitive impairment (AICI) by alleviating oxidative stress and inflammation in the brain and improving hippocampal synaptic plasticity in Sprague–Dawley rats

Defeng Xu and Mouming Zhao

Food Funct., 2022, 13, 11615
DOI: 10.1039/D2FO01709A

Glucocorticoid receptor-mediated alleviation of inflammation by berberine: in vitro, in silico and in vivo investigations

Yuan Liang, Tiehua Zhang, Jingqi Zhao, Chenfei Li, Haoyang Zou, Fangyu Li, Jie Zhang and Li Ren

Food Funct., 2021, 12, 11974
DOI: 10.1039/D1FO01612A

Confusoside, a dihydrochalcone glucoside, prevents acetaminophen-induced liver injury by modulating the Nrf2/NF-κB/caspase signaling pathway

Jinghao Zhao, Shang Shi, Xiaoyu Zhang, Yaping Liu, Minglong Yuan, Guiguang Cheng and Yudan Wang

Food Funct., 2023, 14, 2432
DOI: 10.1039/D2FO03497B

Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation

Huiyi Li, Qiqing Weng, Shuai Gong, Weixian Zhang, Jiaqi Wang, Yuqiao Huang, Yuanjun Li, Jiao Guo and Tian Lan

Food Funct., 2023, 14, 1884
DOI: 10.1039/D2FO02716J

Hepatoprotective effects of methanolic extract of green tea against Thioacetamide-Induced liver injury in Sprague Dawley rats

Suhayla Hamad Shareef, Ibrahim Abdel Aziz Ibrahim, Abdullah R. Alzahrani, Morteta H. Al-Medhtiy and Mahmood Ameen Abdulla

Saudi Journal of Biological Sciences, 2022, 29, 564
DOI: 10.1016/j.sjbs.2021.09.023

Protective effect of hot-water and ethanol-aqueous extracts from Anneslea fragrans against acetaminophen-induced acute liver injury in mice

Yiwen Hu, Mengcheng Li, Yongpeng Wang, Qingwang Xue, Xiaodong Luo, Afsar Khan, Tianrui Zhao, Yaping Liu, Zhengxuan Wang, Yudan Wang and Guiguang Cheng

Food and Chemical Toxicology, 2023, 179, 113973
DOI: 10.1016/j.fct.2023.113973

Natural Products for Acetaminophen-Induced Acute Liver Injury: A Review

Xiaoyangzi Li, Ruyang Lao, Jiawei Lei, Yuting Chen, Qi Zhou, Ting Wang and Yingpeng Tong

Molecules, 2023, 28, 7901
DOI: 10.3390/molecules28237901

Quinic acid alleviates liver toxicity induced by acetaminophen in mice via anti-oxidative and anti-inflammatory effects

Saeedeh Shariati, Shokooh Mohtadi, Mohammad Javad Khodayar, Maryam Salehcheh, Reza Azadnasab, Esrafil Mansouri and Mehrnoosh Moosavi

Naunyn-Schmiedeberg's Arch Pharmacol, 2025, 398, 10367
DOI: 10.1007/s00210-025-03869-7

Que Zui tea ameliorates hepatic lipid accumulation and oxidative stress in high fat diet induced nonalcoholic fatty liver disease

Jin-Ke Zhang, Xiu-Li Zhou, Xiao-Qian Wang, Jia-Xiong Zhang, Mei-Lian Yang, Ya-Ping Liu, Jian-Xin Cao and Gui-Guang Cheng

Food Research International, 2022, 156, 111196
DOI: 10.1016/j.foodres.2022.111196

Theragra chalcogramma Hydrolysates, Rich of Fragment Gly-Leu-Pro-Ser-Tyr-Thr, Ameliorate Alcohol-Induced Cognitive Impairment via Attenuating Neuroinflammation and Enhancing Neuronal Plasticity in Sprague–Dawley Rats

Defeng Xu and Mouming Zhao

J. Agric. Food Chem., 2022, 70, 12513
DOI: 10.1021/acs.jafc.2c05163

Pien Tze Huang attenuated acetaminophen-induced liver injury by autophagy mediated-NLRP3 inflammasome inhibition

Ruowei Zhao, Qing Zhang, Wenjing Liu, Yifan Lin, Yuhui He, Dennis Chang, Shaohua Li, Wen Xu, Yanxiang Lin, Yanfang Zheng, Xian Zhou and Mingqing Huang

Journal of Ethnopharmacology, 2023, 311, 116285
DOI: 10.1016/j.jep.2023.116285

Revealing the dynamic changes of metabolites and molecular mechanisms of chlorogenic acid accumulation during the leaf development of Vaccinium dunalianum based on multi-omic analyses

Anmian Zhang, Jiaxin Liu, Weicheng Li, Lihong Yang, Wenjin Duan, Ping Zhao, Zhiyu Pu and Yong Ding

Front. Plant Sci., 2024, 15
DOI: 10.3389/fpls.2024.1440589

Ethanolic Extract from Pteris wallichiana Alleviates DSS-Induced Intestinal Inflammation and Intestinal Barrier Dysfunction by Inhibiting the TLR4/NF-κB Pathway and Regulating Tight Junction Proteins

Junhong Tao, Zhihua Huang, Yudan Wang, Yaping Liu, Tianrui Zhao, Yifen Wang, Lei Tian and Guiguang Cheng

Molecules, 2022, 27, 3093
DOI: 10.3390/molecules27103093

Sinomenine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress, inflammation and apoptosis in mice

Hui Fan, Tingting Tu, Xiao Zhang, Qiankun Yang, Gang Liu, Tianmeng Zhang, Yu Bao, Yuhe Lu, Zibo Dong, Jingquan Dong and Panpan Zhao

Food and Chemical Toxicology, 2022, 159, 112759
DOI: 10.1016/j.fct.2021.112759

Novel carvedilol-loaded pro-phytomicelles: formulation, characterization and enhanced protective efficacy against acetaminophen-induced liver injury in mice

Hanzhang Teng, Liping Zhou, Cuicui Wang, Zhixin Yuan, Qilong Cao, Xianggen Wu and Mengshuang Li

International Journal of Pharmaceutics, 2022, 625, 122127
DOI: 10.1016/j.ijpharm.2022.122127

A Comparative Analysis of Chemical Constituents and Antioxidant Effects of Dendrobium fimbriatum Hook Fractions with Different Polarities

Tianrui Zhao, Fangyuan Zheng, Yaping Liu, Afsar Khan, Zhengxuan Wang and Guiguang Cheng

IJMS, 2023, 24, 12646
DOI: 10.3390/ijms241612646

E se tea aqueous-ethanol extract ameliorates D-galactose induced oxidative stress and inflammation via the Nrf2 signal pathway

Guiguang Cheng, Meng Zhang, Jinke Zhang, Sifan Teng, Zhengxuan Wang, Tianqi Cui and Shanshan Xiao

Food Research International, 2025, 209, 116323
DOI: 10.1016/j.foodres.2025.116323

Extract of Triticum aestivum Sprouts Suppresses Acetaminophen-Induced Hepatotoxicity in Mice by Inhibiting Oxidative Stress

Ji-Ye Lim, Dae-Ho Yun, Ji-Hyun Lee, Young-Bae Kwon, Young-Mi Lee, Dong-Hyun Lee and Dae-Ki Kim

Molecules, 2021, 26, 6336
DOI: 10.3390/molecules26216336

The Protective Effect and Mechanism of a Phytochemical Extract from the Wild Vegetable Shutou (Crateva unilocularis Buch.) against Acetaminophen-Induced Liver Injury in Mice

Meimei Shan, Qian Ma, Yilin Sun, Fengyi Gao and Shengbao Cai

Foods, 2023, 12, 3109
DOI: 10.3390/foods12163109

Protective Effect of Que Zui Tea on d-Galactose-Induced Oxidative Stress Damage in Mice via Regulating SIRT1/Nrf2 Signaling Pathway

Yongchao Wang, Yongpeng Wang, Tianrui Zhao, Mengcheng Li, Yudan Wang, Jianxin Cao, Yaping Liu, Zhengxuan Wang and Guiguang Cheng

Molecules, 2024, 29, 1384
DOI: 10.3390/molecules29061384

Bioactivity-Guided Isolation of Phytochemicals from Vaccinium dunalianum Wight and Their Antioxidant and Enzyme Inhibitory Activities

Tianrui Zhao, Mengxue Sun, Lingpeng Kong, Qingwang Xue, Yudan Wang, Yifen Wang, Afsar Khan, Jianxin Cao and Guiguang Cheng

Molecules, 2021, 26, 2075
DOI: 10.3390/molecules26072075

Protective effects of E Se tea extracts against alcoholic fatty liver disease induced by high fat/alcohol diet: In vivo biological evaluation and molecular docking study

Yongpeng Wang, Zhifeng Fan, Meilian Yang, Yudan Wang, Jianxin Cao, Afsar Khan, Yaping Liu and Guiguang Cheng

Phytomedicine, 2022, 101, 154113
DOI: 10.1016/j.phymed.2022.154113

Subcritical Water Extraction of Phenolic Compounds from Vaccinium Dunalianum Wight Leaves and Their Antioxidant and Tyrosinase Inhibitory Activities in Vitro

Xiaoqin Yang, Wenbo Wang, Qian Jiang, Sida Xie, Ping Zhao, Zhen Liu, Guolei Zhu, Junming Xu, Jieyu Wang and Yonghe Li

Chemistry & Biodiversity, 2023, 20
DOI: 10.1002/cbdv.202201099

Trilobatin as a potential adjuvant therapy for NAFLD: Targeting AMPK-PPARα and Nrf2 antioxidant pathways

Jinghao Zhao, Xiaoyu Zhang, Shang Shi, Minglong Yuan, Guiguang Cheng and Yudan Wang

Food Bioscience, 2025, 63, 105598
DOI: 10.1016/j.fbio.2024.105598

The structures of two glucomannans from Bletilla formosana and their protective effect on inflammation via inhibiting NF-κB pathway

Qinghui Gu, Yaping Liu, Li Zhen, Tianrui Zhao, Lan Luo, Junyin Zhang, Tuo Deng, Mingyi Wu, Guiguang Cheng and Jiangmiao Hu

Carbohydrate Polymers, 2022, 292, 119694
DOI: 10.1016/j.carbpol.2022.119694

The investigation on an ethnic medicinal plant of Elsholtiza bodinieri Vaniot: Chemical constituents, acute, 28-day subacute and 90-day subchronic toxicity evaluation

Taiming Chen, Sifan Teng, Hailin Yang, Yunli Zhao, Jiaxiong Zhang, Jueting Liu, Wenbing Zhou, Yaping Liu and Guiguang Cheng

Journal of Ethnopharmacology, 2024, 335, 118635
DOI: 10.1016/j.jep.2024.118635

A review on pharmacological activities and synergistic effect of quercetin with small molecule agents

Haoyang Zou, Haiqing Ye, Rajamanikkam Kamaraj, Tiehua Zhang, Jie Zhang and Petr Pavek

Phytomedicine, 2021, 92, 153736
DOI: 10.1016/j.phymed.2021.153736

Herbal management of TAA-induced liver toxicity: Fibrosis, cirrhosis, and hepatocellular carcinoma

Ahmed A. Mohamed, Aly A. Shoun, Rana A. El-Kadi, Sandra O. Abd El-Maseh and Shimaa A. Abass

Pathology - Research and Practice, 2025, 273, 156141
DOI: 10.1016/j.prp.2025.156141

Serum albumin complexed with ellagic acid from pomegranate peel and its metabolite urolithin B

Peiyu Xue, Guangjie Zhang, Hongmei Zhao, Wencheng Wang, Jie Zhang and Li Ren

Food Bioscience, 2022, 46, 101618
DOI: 10.1016/j.fbio.2022.101618

Dietary phytochemicals as modulators of human pregnane X receptor

Jie Zhang, Petr Pavek, Rajamanikkam Kamaraj, Li Ren and Tiehua Zhang

Critical Reviews in Food Science and Nutrition, 2023, 63, 3279
DOI: 10.1080/10408398.2021.1995322

Antihyperlipidemic effect of Vaccinium dunalianum buds based on biological activity screening and LC-MS

Jin-Han Yang, Tong-Chen Bai, Lu-Li Shi, Bo Hou, Ran Tang, Rong-Ping Zhang and Xing-Long Chen

Journal of Ethnopharmacology, 2023, 306, 116190
DOI: 10.1016/j.jep.2023.116190

Arbutin derivatives from the buds of Vaccinium dunalianum and their MS/MS spectrometric fragmentations

Bo Yang, Rong-Ping Zhang, Guo-Feng Ren and Xing-Long Chen

Phytochemistry Letters, 2022, 50, 1
DOI: 10.1016/j.phytol.2022.05.001

Green Tea Reduces TNF-Alpha and IL-6 Inflammatory Cytokines Induced by Ethyl Alcohol Toxication in Rats

Eda Yildizhan, Burak Veli Ülger, Murat Akkuş, Senem Çetin Duran, Uğur Şeker, Nilüfer Dönmezdil and Muhammed Emir Ceylan

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi, 2026, 12, 41
DOI: 10.30934/kusbed.1763448

Effect of ultra-high pressure pretreatment on the phenolic profiles, antioxidative activity and cytoprotective capacity of different phenolic fractions from Que Zui tea

Yongpeng Wang, Zhengxuan Wang, Qingwang Xue, Li Zhen, Yudan Wang, Jianxin Cao, Yaping Liu, Afsar Khan, Tianrui Zhao and Guiguang Cheng

Food Chemistry, 2023, 409, 135271
DOI: 10.1016/j.foodchem.2022.135271

Sophorae tonkinensis radix polysaccharide attenuates acetaminophen-induced liver injury by regulating the miR-140-5p-related antioxidant mechanism

Liangliang Cai, Lixing Xu, Kai Shen, Qin Wang, Ronghua Ni, Xin Xu and Xiaofei Ma

Journal of Traditional and Complementary Medicine, 2024, 14, 467
DOI: 10.1016/j.jtcme.2024.01.006

Evaluation of Acute and Subacute Toxicity of Two Different Extracts from Que Zui Tea in Rats

Yongpeng Wang, Guy Sedar Singor Njateng, Tianrui Zhao, Meilian Yang, Yifen Wang, Jianxin Cao, Yaping Liu and Guiguang Cheng

eFood, 2021, 2, 81
DOI: 10.2991/efood.k.210329.002

Chemical Profiling and Hepatoprotective Potential of Chloroform–Methanolic Extract of Salvia sclarea L.: GC–MS Analysis and In Vivo Studies

Nasir Nisar, Suhail Maqbool, Suhail Ahmad Mir, Showkat Ahmad Shah and Nahida Tabassum

Chemistry & Biodiversity, 2025
DOI: 10.1002/cbdv.202403496

Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation

Yilin Sun, Shengbao Cai, Yuanyue Zhang, Nan Ma, Junjie Yi, Xiaosong Hu and Tao Wang

Nutrients, 2022, 14, 4090
DOI: 10.3390/nu14194090

Eriodictyol Alleviated LPS/D-GalN-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Cell Apoptosis via PI3K/AKT Signaling Pathway

Xiaomei Zheng, Xinyan Wu, Qiqi Wen, Huaqiao Tang, Ling Zhao, Fei Shi, Yinglun Li, Zhongqiong Yin, Yuanfeng Zou, Xu Song, Lixia Li, Xinghong Zhao and Gang Ye

Nutrients, 2023, 15, 4349
DOI: 10.3390/nu15204349

Confusoside from Anneslea fragrans Alleviates Acetaminophen-Induced Liver Injury in HepG2 via PI3K-CASP3 Signaling Pathway

Jing-Hao Zhao, Jing Li, Xiao-Yu Zhang, Shang Shi, Lin Wang, Ming-Long Yuan, Ya-Ping Liu and Yu-Dan Wang

Molecules, 2023, 28, 1932
DOI: 10.3390/molecules28041932

Non-targeted metabolomics profiling of Vaccinium dunalianum Wight: UPLC-MS/MS analysis of metabolite variability across different tissues

Chuanhui Yao, Yanhua Yu, Dong Xie, Xuefei An, Jiao Xia, Ping Zhao, Lihua Zou, Sida Xie, Jun Feng and Xiaoqin Yang

Natural Product Research, 2025, 1
DOI: 10.1080/14786419.2025.2588333

Mn3O4 nanozymes prevent acetaminophen-induced acute liver injury by attenuating oxidative stress and countering inflammation

Menghua Liu, Haitao Wu, Qianhui Li, Hang Liu, Chongqing Chen, Fan Yin, Hua Wang, Zhengbao Zha and Fei Wang

Journal of Colloid and Interface Science, 2024, 654, 83
DOI: 10.1016/j.jcis.2023.10.019

Protective effect of Tibetan medicine Qiwei Tiexie pills on liver injury induced by acetaminophen overdose: An integrated strategy of network pharmacology, metabolomics and transcriptomics

Xingbo Bian, Lizhu Chen, Xuefeng Bian, Lele Li, Dan Liu, Siying Liu, Lu Xu, Xuyang Huo and Xiaohang Yang

Phytomedicine, 2024, 123, 155221
DOI: 10.1016/j.phymed.2023.155221

6′-O-Caffeoylarbutin from Quezui Tea: A Highly Effective and Safe Tyrosinase Inhibitor

Dong Xie, Wengan Fu, Tiantian Yuan, Kangjia Han, Yuxiu Lv, Qi Wang, Qian Jiang, Yingjun Zhang, Guolei Zhu, Junming Xu, Ping Zhao and Xiaoqin Yang

IJMS, 2024, 25, 972
DOI: 10.3390/ijms25020972

Amelioration of oxidative stress by trans-Anethole via modulating phase I and phase II enzymes against hepatic damage induced by CCl4 in male Wistar rats

Kritika Pandit, Ajay Kumar, Sandeep Kaur, Vinod Kumar, Subheet Kumar Jain, Renu Bhardwaj and Satwinderjeet Kaur

Environ Sci Pollut Res, 2022, 29, 6317
DOI: 10.1007/s11356-021-16070-z

Integrating Metabolomics and Network Pharmacology to Decipher the Hepatoprotective Effect Mechanisms of Magnesium Isoglycyrrhizinate Injection

Yihua Zhang, Hui Li, Xueli Liu, Qiang Wang, Dong Zhao, Ming Su, Zhixin Jia and Shigang Shen

CIMB, 2023, 46, 279
DOI: 10.3390/cimb46010019

GR-mediated anti-inflammation of α-boswellic acid: Insights from in vitro and in silico studies

Jie Zhang, Jiarui Zhao, Yantong Sun, Yuan Liang, Jingqi Zhao, Haoyang Zou, Tiehua Zhang and Li Ren

Food and Chemical Toxicology, 2021, 155, 112379
DOI: 10.1016/j.fct.2021.112379

Regulation of Hazelnut Leaf Polyphenols on Oxidative Stress in Chronic Alcoholic Liver Injury

Bo‐ming Liang, Mu‐yao Wang, Chang‐cheng Ji, Xin Qi and Cheng‐bi Cui

eFood, 2025, 6
DOI: 10.1002/efd2.70053

Optimization of clofibrate with natural product sesamol for reducing liver injury induced by acetaminophen

Chuchu Han, Linyang Zhang, Yuxin Hua, Haitao Liu, Jiping Liu, Yongheng Shi, Xiaoping Wang, Wei Wang, Yi Jiang, Huawei Zhang, Chong Deng, Yundong Xie, Shipeng He and Ying Liu

Med Chem Res, 2023, 32, 38
DOI: 10.1007/s00044-022-02989-6