Issue 35, 2024

Broad-spectrum degradation of fluoroquinolone antibiotics by Hemin-His-Fe nanozymes with peroxidase-like activity

Abstract

Fluoroquinolones are a widely used class of antibiotics, with a large variety, which are frequently monitored in the aqueous environment, threatening ecological and human health. To date, effective degradation of fluoroquinolone antibiotics remains a major challenge. Focused on the broad-spectrum degradation of fluoroquinolone antibiotics, a novel biomimetic peroxidase nanozyme named Hemin-His-Fe (HHF)-peroxidase nanozyme was synthesized through a green and rapid “one-pot” method involving hemin, Fmoc-L-His and Fe2+ as precursors. After systematic optimization of the reaction conditions, fluoroquinolone antibiotics can be degraded by the HHF-peroxidase nanozyme when supplemented with H2O2 in acidic environments. Through validation and analysis, it was proved that the generated strong oxidative hydroxyl radicals are the main active species in the degradation process. In addition, it was verified that this method shows great universal applicability in real water samples.

Graphical abstract: Broad-spectrum degradation of fluoroquinolone antibiotics by Hemin-His-Fe nanozymes with peroxidase-like activity

Supplementary files

Article information

Article type
Paper
Submitted
09 Kul 2024
Accepted
15 Maw 2024
First published
17 Maw 2024

J. Mater. Chem. B, 2024,12, 8647-8654

Broad-spectrum degradation of fluoroquinolone antibiotics by Hemin-His-Fe nanozymes with peroxidase-like activity

X. Geng, K. Song, Q. Hu, Y. Yin, H. Li, X. Yan and B. Jiang, J. Mater. Chem. B, 2024, 12, 8647 DOI: 10.1039/D4TB00508B

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