Issue 19, 2024

Engineering poly(ethylene glycol) particles for targeted drug delivery

Abstract

Poly(ethylene glycol) (PEG) is considered to be the “gold standard” among the stealth polymers employed for drug delivery. Using PEG to modify or engineer particles has thus gained increasing interest because of the ability to prolong blood circulation time and reduce nonspecific biodistribution of particles in vivo, owing to the low fouling and stealth properties of PEG. In addition, endowing PEG-based particles with targeting and drug-loading properties is essential to achieve enhanced drug accumulation at target sites in vivo. In this feature article, we focus on recent work on the synthesis of PEG particles, in which PEG is the main component in the particles. We highlight different synthesis methods used to generate PEG particles, the influence of the physiochemical properties of PEG particles on their stealth and targeting properties, and the application of PEG particles in targeted drug delivery.

Graphical abstract: Engineering poly(ethylene glycol) particles for targeted drug delivery

Article information

Article type
Feature Article
Submitted
14 N’w 2023
Accepted
22 Sun 2024
First published
23 Sun 2024

Chem. Commun., 2024,60, 2591-2604

Engineering poly(ethylene glycol) particles for targeted drug delivery

S. Li, Y. Ma, J. Cui, F. Caruso and Y. Ju, Chem. Commun., 2024, 60, 2591 DOI: 10.1039/D3CC06098E

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