Issue 21, 2023

Small-molecule fluorescent probes for bioactive species in inflammatory disease: arthritis, pneumonia and hepatitis

Abstract

Inflammation as an adaptive response underlies a wide variety of physiological and pathological processes. The progression of inflammation is closely intertwined with various bioactive molecules. To dissect the biological mechanisms and physiopathological functions of these molecules, exploitation of versatile detection mean is of great importance. Fluorescence imaging technique has been widely employed to track bioactive species in living systems. As a result, many small-molecule fluorescent probes for bioactive species in inflammatory disease have been developed. However, this interesting and frontier topic hasn't been systematically categorized. Therefore, in this review, we have generalized the construction strategies and biological imaging applications of small-molecule fluorescent probes for various bioactive species, including reactive oxygen/nitrogen/sulfur species, enzyme, mainly in arthritis, pneumonia and hepatitis. Moreover, the future challenges in constructing novel fluorescent probes for inflammatory disease are also present. This review will facilitate the comprehension of superior fluorescent probes for active molecules associated with inflammation.

Graphical abstract: Small-molecule fluorescent probes for bioactive species in inflammatory disease: arthritis, pneumonia and hepatitis

Supplementary files

Article information

Article type
Minireview
Submitted
28 Maw 2023
Accepted
08 Ndz 2023
First published
05 Nhl 2023

Analyst, 2023,148, 5303-5321

Small-molecule fluorescent probes for bioactive species in inflammatory disease: arthritis, pneumonia and hepatitis

X. Zhang, F. Tang, W. Shu, D. Li, Y. Liu, H. Xiao, J. Zhou and P. Li, Analyst, 2023, 148, 5303 DOI: 10.1039/D3AN01289A

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