Issue 4, 2022

Laser ablation-ICP-mass spectrometry for determination of the concentrations and spatial distributions of bromine and iodine in human hair

Abstract

Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) was applied for the determination of Br and I in hair strands of human individuals under treatment with synthetic thyroid hormones. Quantification relied on the use of Br- and I-spiked human hair strands prepared in-house as matrix-matched external calibration standards. The results obtained via LA-ICP-MS agreed with the corresponding Br and I concentrations as determined via pneumatic nebulization-ICP-MS after digestion via microwave-induced combustion. The spatial distributions of Br and I in the spiked hair standards were evaluated by spatially resolved LA-ICP-MS analysis and a homogeneous distribution was established upon scanning longitudinally along the hair strands and across the cross-section. Twenty-five human hair strands from volunteers were analyzed by LA-ICP-MS (7 individuals with hypothyroidism under treatment with synthetic thyroid hormones and 18 individuals considered healthy), and those from subjects under treatment with synthetic thyroid hormones presented a higher I concentration than those from subjects considered healthy. Limits of detection were 0.36 μg g−1 for Br and 0.14 μg g−1 for I, allowing trace level determination in human hair.

Graphical abstract: Laser ablation-ICP-mass spectrometry for determination of the concentrations and spatial distributions of bromine and iodine in human hair

Supplementary files

Article information

Article type
Paper
Submitted
16 N’w 2021
Accepted
17 Yan 2022
First published
18 Yan 2022

J. Anal. At. Spectrom., 2022,37, 775-782

Laser ablation-ICP-mass spectrometry for determination of the concentrations and spatial distributions of bromine and iodine in human hair

D. L. R. Novo, T. Van Acker, J. Belza, F. Vanhaecke and M. F. Mesko, J. Anal. At. Spectrom., 2022, 37, 775 DOI: 10.1039/D1JA00441G

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