Issue 8, 2022

Coordination effect enabled palladium-catalyzed regioselective O-alkylation of 2-pyridones

Abstract

A novel tactic for the regioselective O-alkylation of 2-pyridones has been realized through palladium catalysis in moderate to high yields. The coordination effect between palladium and nitrogen on the pyridine ring plays a versatile role.

Graphical abstract: Coordination effect enabled palladium-catalyzed regioselective O-alkylation of 2-pyridones

Supplementary files

Article information

Article type
Communication
Submitted
01 Huk 2021
Accepted
17 N’w 2021
First published
20 N’w 2021

Chem. Commun., 2022,58, 1215-1218

Coordination effect enabled palladium-catalyzed regioselective O-alkylation of 2-pyridones

Z. Lu, Y. Li, Y. Ru, S. Yang, C. Hao, M. Zuo, R. Jiao, W. Wu, Y. Zhou, H. Yao, N. Huang and Y. Fu, Chem. Commun., 2022, 58, 1215 DOI: 10.1039/D1CC06110K

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