Issue 1, 2022

Cp*Rh(iii)/boron hybrid catalysis for directed C–H addition to β-substituted α,β-unsaturated carboxylic acids

Abstract

The C–H bond addition reaction of 2-phenylpyridine derivatives with α,β-unsaturated carboxylic acids catalyzed by Cp*Rh(III)/BH3·SMe2 is reported. Activation of C–H bonds with the rhodium catalyst and activation of α,β-unsaturated carboxylic acids with the boron catalyst cooperatively work, and a BINOL-urea hybrid ligand significantly improved the reactivity. With the optimized hybrid catalytic system, various β-disubstituted carboxylic acids were obtained under mild reaction conditions.

Graphical abstract: Cp*Rh(iii)/boron hybrid catalysis for directed C–H addition to β-substituted α,β-unsaturated carboxylic acids

Supplementary files

Article information

Article type
Communication
Submitted
22 Nhl 2021
Accepted
29 Huk 2021
First published
29 Huk 2021

Chem. Commun., 2022,58, 76-79

Cp*Rh(III)/boron hybrid catalysis for directed C–H addition to β-substituted α,β-unsaturated carboxylic acids

R. Tanaka, Y. Hirata, M. Kojima, T. Yoshino and S. Matsunaga, Chem. Commun., 2022, 58, 76 DOI: 10.1039/D1CC05956D

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