Issue 10, 2022

Recent advances in spheroid-based microfluidic models to mimic the tumour microenvironment

Abstract

Three-dimensional (3D) multicellular spheroid models can recapitulate the human tumour microenvironment with more accuracy than conventional cell culture models, as they include complex architectural structures and dynamic cellular interactions. Among the diverse platforms for spheroid formation, microfluidic platforms have been extensively applied to study spheroids because they can mimic the in vivo microenvironment. This review provides an overview of the advantages of 3D spheroid cultures with a summary of the recent applications for tumour microenvironment-focused cellular interactions, as well as the studies on spheroids and external stimuli. These 3D tumour spheroid-based microfluidic devices will provide a platform for a better understanding of cellular and external interactions, as well as the discovery of cancer therapeutics.

Graphical abstract: Recent advances in spheroid-based microfluidic models to mimic the tumour microenvironment

Article information

Article type
Minireview
Submitted
26 Sun 2022
Accepted
20 Dzi 2022
First published
21 Dzi 2022

Analyst, 2022,147, 2023-2034

Recent advances in spheroid-based microfluidic models to mimic the tumour microenvironment

J. Ro, J. Kim and Y. Cho, Analyst, 2022, 147, 2023 DOI: 10.1039/D2AN00172A

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