Ru(TAP)32+ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA

Willem Vanderlinden; Pauline J. Kolbeck; Wout Frederickx; Sebastian F. Konrad; Thomas Nicolaus; Carola Lampe; Alexander S. Urban; Cécile Moucheron; Jan Lipfert

doi:10.1039/C9CC02838B

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Ru(TAP)₃²⁺ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA†

Willem Vanderlinden,

*^ab Pauline J. Kolbeck,^a Wout Frederickx,^b Sebastian F. Konrad,^a Thomas Nicolaus,^a Carola Lampe,^a Alexander S. Urban,

^a Cécile Moucheron^c and Jan Lipfert

Author affiliations

* Corresponding authors

^a Department of Physics, Nanosystems Initiative Munich, and Center for NanoScience, LMU Munich, Amalienstrasse 54, 80799 Munich, Germany

^b Department of Chemistry, Division of Molecular Imaging and Photonics, KU Leuven-University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium
E-mail: willem.vanderlinden@kuleuven.be

^c Department of Chemistry, Laboratory of Organic Chemistry and Photochemistry, Université Libre de Bruxelles, Avenue Franklin D. Roosevelt 50, 1050 Brussels, Belgium

Abstract

Ru(II)-complexes with polyazaaromatic ligands can undergo direct electron transfer with guanine nucleobases on blue light excitation that results in DNA lesions with phototherapeutic potential. Here we use single molecule approaches to demonstrate DNA binding mode heterogeneity and evaluate how multivalent binding governs the photochemistry of [Ru(TAP)₃]²⁺ (TAP = 1,4,5,8-tetraazaphenanthrene).

This article is part of the themed collection: 2019 Emerging Investigators

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Article information

DOI: https://doi.org/10.1039/C9CC02838B
Article type: Communication
Submitted: 12 Dzi 2019
Accepted: 17 Mud 2019
First published: 17 Mud 2019

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Chem. Commun., 2019,55, 8764-8767

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Ru(TAP)₃²⁺ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA

W. Vanderlinden, P. J. Kolbeck, W. Frederickx, S. F. Konrad, T. Nicolaus, C. Lampe, A. S. Urban, C. Moucheron and J. Lipfert, Chem. Commun., 2019, 55, 8764 DOI: 10.1039/C9CC02838B

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