Issue 28, 2017

Collagen mimetic peptide discs promote assembly of a broad range of natural protein fibers through hydrophobic interactions

Abstract

Collagen mimetic peptides that alone formed two-dimensional nanoscale discs driven by hydrophobic interactions were shown in electron microscopy studies to also co-assemble with natural fibrous proteins to produce discs-on-a-string (DoS) nanostructures. In most cases, peptide discs also facilitated bundling of the protein fibers. This provides insight into how synthetic and natural proteins may be combined to develop multicomponent, multi-dimensional architectures at the nanoscale.

Graphical abstract: Collagen mimetic peptide discs promote assembly of a broad range of natural protein fibers through hydrophobic interactions

Supplementary files

Article information

Article type
Communication
Submitted
03 Mud 2017
Accepted
28 Kho 2017
First published
29 Kho 2017

Org. Biomol. Chem., 2017,15, 5893-5898

Collagen mimetic peptide discs promote assembly of a broad range of natural protein fibers through hydrophobic interactions

K. McGuinness and V. Nanda, Org. Biomol. Chem., 2017, 15, 5893 DOI: 10.1039/C7OB01073G

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