Issue 54, 2016

Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

Abstract

[18F]FMTEB, [18F]FPEB, [18F]flumazenil, [18F]DAA1106, [18F]MFBG, [18F]FDOPA, [18F]FMT and [18F]FDA are prepared from the corresponding arylboronic esters and [18F]KF/K222 in the presence of Cu(OTf)2py4. The method was successfully applied using three radiosynthetic platforms, and up to 26 GBq of non-carrier added starting activity of 18F-fluoride.

Graphical abstract: Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

Supplementary files

Article information

Article type
Communication
Submitted
19 Dzi 2016
Accepted
23 Mud 2016
First published
23 Mud 2016

Chem. Commun., 2016,52, 8361-8364

Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

S. Preshlock, S. Calderwood, S. Verhoog, M. Tredwell, M. Huiban, A. Hienzsch, S. Gruber, T. C. Wilson, N. J. Taylor, T. Cailly, M. Schedler, T. L. Collier, J. Passchier, R. Smits, J. Mollitor, A. Hoepping, M. Mueller, C. Genicot, J. Mercier and V. Gouverneur, Chem. Commun., 2016, 52, 8361 DOI: 10.1039/C6CC03295H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements