Issue 5, 2024

Serum antibody screening using glycan arrays

Abstract

Humans and other animals produce a diverse collection of antibodies, many of which bind to carbohydrate chains, referred to as glycans. These anti-glycan antibodies are a critical part of our immune systems’ defenses. Whether induced by vaccination or natural exposure to a pathogen, anti-glycan antibodies can provide protection against infections and cancers. Alternatively, when an immune response goes awry, antibodies that recognize self-glycans can mediate autoimmune diseases. In any case, serum anti-glycan antibodies provide a rich source of information about a patient's overall health, vaccination history, and disease status. Glycan microarrays provide a high-throughput platform to rapidly interrogate serum anti-glycan antibodies and identify new biomarkers for a variety of conditions. In addition, glycan microarrays enable detailed analysis of the immune system's response to vaccines and other treatments. Herein we review applications of glycan microarray technology for serum anti-glycan antibody profiling.

Graphical abstract: Serum antibody screening using glycan arrays

Article information

Article type
Review Article
Submitted
24 Mha 2023
First published
02 Yan 2024

Chem. Soc. Rev., 2024,53, 2603-2642

Serum antibody screening using glycan arrays

S. Marglous, C. E. Brown, V. Padler-Karavani, R. D. Cummings and J. C. Gildersleeve, Chem. Soc. Rev., 2024, 53, 2603 DOI: 10.1039/D3CS00693J

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