NIR luminogen for low-temperature photothermal therapy by triggering HSP90α down-regulation

Xinzhe Yang; Keke Ding; Guiquan Zhang; Pengbo Han; Rong Hu; Zhiming Wang; Anjun Qin; Ben Zhong Tang

doi:10.1039/D2CC06932F

NIR luminogen for low-temperature photothermal therapy by triggering HSP90α down-regulation†

Xinzhe Yang,‡^ab Keke Ding,‡^f Guiquan Zhang,^ab Pengbo Han,^ab Rong Hu,*^abe Zhiming Wang,

^ab Anjun Qin

*^ab and Ben Zhong Tang*^bcd

Author affiliations

* Corresponding authors

^a State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou, China
E-mail: msqinaj@scut.edu.cn, hurong@usc.edu.cn

^b Center for Aggregation-Induced Emission, AIE Institute, South China University of Technology, Guangzhou, China

^c School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen, Guangdong, China
E-mail: tangbenz@cuhk.edu.cn

^d Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China

^e School of Chemistry and Chemical Engineering, University of South China, Hengyang, China

^f Department of Urology, The First Affiliated Hospital of Soochow University, NO. 188 Shizi Road, Suzhou, China

Abstract

A near-infrared (NIR) luminogen TST was designed and used to efficiently trigger HSP90α protein knockdown through photo-thermal conversion based on a gene interference strategy, by which in vitro and in vivo tumor ablation were significantly acquired at low-temperature.

This article is part of the themed collection: Photofunctional Materials and Transformations

Supplementary files

Article information

DOI: https://doi.org/10.1039/D2CC06932F
Article type: Communication
Submitted: 20 N’w 2022
Accepted: 27 Sun 2023
First published: 30 Sun 2023

Download Citation

Chem. Commun., 2023,59, 2743-2746

Permissions

Request permissions

NIR luminogen for low-temperature photothermal therapy by triggering HSP90α down-regulation

X. Yang, K. Ding, G. Zhang, P. Han, R. Hu, Z. Wang, A. Qin and B. Z. Tang, Chem. Commun., 2023, 59, 2743 DOI: 10.1039/D2CC06932F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Chemical Communications

NIR luminogen for low-temperature photothermal therapy by triggering HSP90α down-regulation†

Abstract

Supplementary files

Article information

Download Citation

Permissions

NIR luminogen for low-temperature photothermal therapy by triggering HSP90α down-regulation

Social activity

Search articles by author

Spotlight

Advertisements