Issue 27, 2022

Direct arylation of N-heterocycles enabled by photoredox catalysis

Abstract

N-Heterobiaryls are common skeletons found in biological molecules, pharmaceuticals and ligands. Herein, we document an efficient and redox-neutral photocatalytic system to obtain functionalized N-heterobiaryls under mild conditions. Substrates bearing variegated functional groups are compatible with the developed photocatalytic conditions. This method is translatable to gram-scale synthesis, with a photocatalyst loading as low as 0.1 mol% and minimal variation of the yield. The starting materials are commercially available, demonstrating the practicality and accessibility of this methodology. Interestingly, phenols can serve both as coupling partners and proton donors. Arenes without a phenolic hydroxyl group also underwent efficient coupling with HFIP as a solvent.

Graphical abstract: Direct arylation of N-heterocycles enabled by photoredox catalysis

Supplementary files

Article information

Article type
Communication
Submitted
28 Yan 2022
Accepted
09 Kul 2022
First published
10 Kul 2022

Chem. Commun., 2022,58, 4392-4395

Direct arylation of N-heterocycles enabled by photoredox catalysis

H. Li, S. Li, J. K. Cheng, S. Xiang and B. Tan, Chem. Commun., 2022, 58, 4392 DOI: 10.1039/D2CC01212J

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