Issue 22, 2021

Selective formation of form II paracetamol through the assistance of paracetamol co-crystals as templates in a solution

Abstract

Selective formation for form II instead of form I paracetamol was promoted through the assistance of structurally related packing motifs and arrangements of paracetamol co-crystals in an aqueous solution. Form II paracetamol was produced by cooling crystallization in water with either oxalic acid or maleic acid. The co-crystal lattice structures of paracetamol with oxalic acid and maleic acid were similar to the packing pattern of form II paracetamol.

Graphical abstract: Selective formation of form II paracetamol through the assistance of paracetamol co-crystals as templates in a solution

Supplementary files

Article information

Article type
Communication
Submitted
08 Sun 2021
Accepted
26 Dzi 2021
First published
28 Dzi 2021

CrystEngComm, 2021,23, 3940-3945

Selective formation of form II paracetamol through the assistance of paracetamol co-crystals as templates in a solution

K. L. Yeh and T. Lee, CrystEngComm, 2021, 23, 3940 DOI: 10.1039/D1CE00034A

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