Issue 38, 2020

Shape-transformation of polymersomes from glassy and crosslinkable ABA triblock copolymers

Abstract

Recent developments in the field of polymer vesicles, i.e. polymersomes, have demonstrated that disrupting the equilibrium conditions of the milieu could lead to shape transformation into stable non-spherical morphologies, bringing on-demand shape control to reality and bearing great promise for cell mimicry and a variety of biomedical applications. Here, we studied the self-assembly behavior of glassy amphiphilic triblock copolymers, poly(ethylene glycol)-block-polystyrene-stat-poly(coumarin methacrylate)-block-poly(ethylene glycol) (PEG-b-P(S-stat-CMA)-b-PEG), and their response to various stimuli. By changing the respective molecular weights of both the hydrophobic P(S-stat-CMA) and the hydrophilic PEG blocks, we varied the hydrophobic volume fraction thereby accessing a range of morphologies from spherical and worm-like micelles, as well as polymersomes. For the latter, we observed that slow osmotic pressure changes induced by dialysis led to a decrease in size while rapid osmotic pressure changes by addition of a PEG fusogen led to morphological transformations into rod-like and tubular polymersomes. We also found out that chemically crosslinking the vesicles before inducing osmotic pressure changes led to the vesicles exhibiting hypotonic shock, atypical for glassy polymersomes. We believe that this approach combining the robustness of triblock copolymers and light-based transformations will help expand the toolbox to design ever more complex biomimetic constructs.

Graphical abstract: Shape-transformation of polymersomes from glassy and crosslinkable ABA triblock copolymers

Supplementary files

Article information

Article type
Paper
Submitted
02 Maw 2020
Accepted
26 Mha 2020
First published
27 Mha 2020

J. Mater. Chem. B, 2020,8, 8914-8924

Author version available

Shape-transformation of polymersomes from glassy and crosslinkable ABA triblock copolymers

T. Chidanguro, E. Ghimire and Y. C. Simon, J. Mater. Chem. B, 2020, 8, 8914 DOI: 10.1039/D0TB01643H

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