Issue 27, 2020

Nanostructures based on vanadium disulfide growing on UCNPs: simple synthesis, dual-mode imaging, and photothermal therapy

Abstract

It remains a great challenge to integrate effective photothermal therapeutic materials with upconversion nanoparticles (UCNPs) into one structure with small size. Herein, a new and simple method was developed to combine the luminescent UCNPs with vanadium disulfide (VS2) heterogeneously growing on the UCNPs. VS2 was grown directly on the surface of UCNPs to obtain oil-soluble nanocomposites, UCNPs@VS2. Then polyethylene glycol (mPEG) was functionalized on the surface of the nanocomposites to improve the water solubility, resulting in the integrated nanostructure UCNPs@VS2-mPEG (with an approximate size of 25 nm) for bioimaging and photothermal therapy in vitro. Importantly, cytotoxicity test results show that the final nanostructure has good biocompatibility. Furthermore, due to the excellent photothermal effects of VS2 and the unique imaging function of UCNPs, the nanostructure shows effective photothermal therapy for HeLa cells and was successfully applied in magnetic resonance imaging and upconversion luminescence imaging in vitro. Therefore, this study demonstrates a simple yet powerful method of growing VS2 on the surface of UCNPs, which provides an effective method to establish one integrated nanostructure with a nanoscale advantage for dual-model bioimaging and treatment.

Graphical abstract: Nanostructures based on vanadium disulfide growing on UCNPs: simple synthesis, dual-mode imaging, and photothermal therapy

Supplementary files

Article information

Article type
Paper
Submitted
16 Dzi 2020
Accepted
25 Mud 2020
First published
26 Mud 2020

J. Mater. Chem. B, 2020,8, 5883-5891

Nanostructures based on vanadium disulfide growing on UCNPs: simple synthesis, dual-mode imaging, and photothermal therapy

S. Wang, W. Xi, Z. Wang, H. Zhao, L. Zhao, J. Fang, H. Wang and L. Sun, J. Mater. Chem. B, 2020, 8, 5883 DOI: 10.1039/D0TB00993H

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