Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Zehua Liu; Yunzhan Li; Wei Li; Wenhua Lian; Marianna Kemell; Sami Hietala; Patrícia Figueiredo; Li Li; Ermei Mäkilä; Ming Ma; Jarno Salonen; Jouni T. Hirvonen; Dongfei Liu; Hongbo Zhang; Xianming Deng; Hélder A. Santos

doi:10.1039/C8MH01145A

Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing†

Zehua Liu,‡^a Yunzhan Li,‡^bc Wei Li,*^a Wenhua Lian,^bc Marianna Kemell,

^d Sami Hietala,

^d Patrícia Figueiredo,^a Li Li,^bc Ermei Mäkilä,^e Ming Ma,

^f Jarno Salonen,^e Jouni T. Hirvonen,^a Dongfei Liu,

^ag Hongbo Zhang,*^hi Xianming Deng*^bc and Hélder A. Santos

*^ag

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* Corresponding authors

^a Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
E-mail: wei.li@helsinki.fi, helder.santos@helsinki.fi

^b State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Fujian, China
E-mail: xmdeng@xmu.edu.cn

^c State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Fujian, China

^d Department of Chemistry, University of Helsinki, Helsinki, Finland

^e Laboratory of Industrial Physics, Department of Physics, University of Turku, Turku, Finland

^f State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China

^g Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland

^h Department of Pharmaceutical Science, Åbo Akademi University, Turku, Finland
E-mail: hongbo.zhang@abo.fi

ⁱ Turku Center of Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

Abstract

Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.

This article is part of the themed collections: Materials Horizons 10th anniversary regional spotlight collection: Europe and Horizons Community Board Themed Collection – Nanobiomedicine

Materials Horizons

Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing†

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Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

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