Issue 60, 2019

A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

Abstract

We report the first dual-responsive 19F MRI and fluorescence imaging probe for cellular hypoxia. The Cu2+-based probe exhibits no 19F MR signal and reduced fluorescence signal due to paramagnetic quenching; however, the probe turns-on in both modes following reduction to Cu+. This bimodal agent can differentiate hypoxic and normoxic cells in both modalities.

Graphical abstract: A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

Supplementary files

Article information

Article type
Communication
Submitted
15 Sun 2019
Accepted
13 Kho 2019
First published
13 Kho 2019

Chem. Commun., 2019,55, 8860-8863

A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

R. T. Kadakia, D. Xie, D. Martinez, M. Yu and E. L. Que, Chem. Commun., 2019, 55, 8860 DOI: 10.1039/C9CC00375D

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