Issue 13, 2018

C8-Guanine modifications: effect on Z-DNA formation and its role in cancer

Abstract

Base modifications are known to affect the structure and function of DNA. C8-guanine adducts from various carcinogenic compounds have been shown to be potent Z-DNA inducers. Hence, it has been hypothesized that Z-DNA plays a role in cancer and other genetic diseases. In this comprehensive review, Z-DNA and the effect of prevalent C8-guanine adducts on the B–Z transition are addressed. The discoveries of Z-DNA binding proteins including ADAR1, E3L, DLM1, and PKZ have suggested the relevance of Z-DNA in living systems. In addition, increasing evidence on the Z-DNA connection to gene transcription and inhibition reveals potential biological functions of the left-handed DNA. Finally, C8-guanine adducts that promote Z-DNA formation can be used as a tool to explore the Z-DNA function and its role in carcinogenesis.

Graphical abstract: C8-Guanine modifications: effect on Z-DNA formation and its role in cancer

Article information

Article type
Review Article
Submitted
04 Sun 2018
Accepted
28 Yan 2018
First published
02 Kul 2018

Org. Biomol. Chem., 2018,16, 2198-2209

Author version available

C8-Guanine modifications: effect on Z-DNA formation and its role in cancer

V. Vongsutilers and P. M. Gannett, Org. Biomol. Chem., 2018, 16, 2198 DOI: 10.1039/C8OB00030A

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