A fluorescent activatable probe for imaging intracellular Mg2+

Ryan Treadwell; Fabio de Moliner; Ramon Subiros-Funosas; Toby Hurd; Kirsten Knox; Marc Vendrell

doi:10.1039/C7OB02965A

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A fluorescent activatable probe for imaging intracellular Mg²⁺

Ryan Treadwell, Fabio de Moliner, Ramon Subiros-Funosas, Toby Hurd, Kirsten Knox and Marc Vendrell
Org. Biomol. Chem., 2018,16, 239-244
DOI: 10.1039/C7OB02965A, Paper

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Abstract | Cited by

An activatable BODIPY probe for in vitro detection and fluorescence cell imaging of free Mg²⁺ without interference from Ca²⁺ is described. Fluorescence amplification of the probe is observed upon detection of physiological concentrations of Mg²⁺ due to reduced rotation of the fluorophore and effective chelation by a quinolizine-based core.

Graphical abstract: A fluorescent activatable probe for imaging intracellular Mg2+

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