Issue 19, 2018

Predicting the impact of structural diversity on the performance of nanodiamond drug carriers

Abstract

Diamond nanoparticles (nanodiamonds) are unique among carbon nanomaterials, and are quickly establishing a niché in the biomedical application domain. Nanodiamonds are non-toxic, amenable to economically viable mass production, and can be interfaced with a variety of functional moieties. However, developmental challenges arise due to the chemical complexity and structural diversity inherent in nanodiamond samples. Nanodiamonds present a narrow, but significant, distribution of sizes, a dizzying array of possible shapes, and a complicated surface containing aliphatic and aromatic carbon. In the past these facts have been cast as hindrances, stalling development until perfectly monodispersed samples could be achieved. Current research has moved in a different direction, exploring ways that the polydispersivity of nanodiamond samples can be used as a new degree of engineering freedom, and understanding the impact our limited synthetic control really has upon structure/property relationships. In this review a series of computational and statistical studies will be summarised and reviewed, to characterise the relationship between chemical complexity, structural diversity and the reactive performance of nanodiamond drug carriers.

Graphical abstract: Predicting the impact of structural diversity on the performance of nanodiamond drug carriers

Article information

Article type
Review Article
Submitted
28 Yan 2018
Accepted
29 Kul 2018
First published
29 Kul 2018

Nanoscale, 2018,10, 8893-8910

Predicting the impact of structural diversity on the performance of nanodiamond drug carriers

A. S. Barnard, Nanoscale, 2018, 10, 8893 DOI: 10.1039/C8NR01688G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements