Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals

Feng-Yuan Wang; Qi Zhang; Zaiyong Zhang; Xiaoyi Gong; Jian-Rong Wang; Xuefeng Mei

doi:10.1039/C8CE00689J

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Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals†

Feng-Yuan Wang,^ab Qi Zhang,

^a Zaiyong Zhang,^a Xiaoyi Gong,^a Jian-Rong Wang

^a and Xuefeng Mei

*^a

Author affiliations

* Corresponding authors

^a Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
E-mail: xuefengmei@simm.ac.cn
Fax: +86 2150807088
Tel: +86 2150800934

^b University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China

Abstract

Three isostructural cocrystals of apremilast, a novel anti-psoriasis oral agent, with nicotinamide, caffeine, and acetylsalicylic acid were successfully designed and synthesized. Both the apparent solubility and intrinsic dissolution rate of apremilast in a pH 2.0 buffer have been improved via the formation of cocrystals.

This article is part of the themed collection: CrystEngComm New Talent

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DOI: https://doi.org/10.1039/C8CE00689J
Article type: Communication
Submitted: 28 Dzi 2018
Accepted: 09 Mha 2018
First published: 09 Mha 2018

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CrystEngComm, 2018,20, 5945-5948

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Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals

F. Wang, Q. Zhang, Z. Zhang, X. Gong, J. Wang and X. Mei, CrystEngComm, 2018, 20, 5945 DOI: 10.1039/C8CE00689J

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Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals†

Abstract

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Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals

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