Issue 2, 2017

Harnessing non-covalent interactions to exert control over regioselectivity and site-selectivity in catalytic reactions

Abstract

Asymmetric catalysis has been revolutionised by the realisation that attractive non-covalent interactions such as hydrogen bonds and ion pairs can act as powerful controllers of enantioselectivity when incorporated into appropriate small molecule chiral scaffolds. Given these tremendous advances it is surprising that there are still a relatively limited number of examples of non-covalent interactions being harnessed for control of regioselectivity or site-selectivity in catalysis, two other fundamental selectivity aspects facing the synthetic chemist. This perspective examines the progress that has been made in this area thus far using non-covalent interactions in conjunction with transition metal catalysis as well as in the context of purely organic catalysts. We hope this will highlight the great potential in this approach for designing selective catalytic reactions.

Graphical abstract: Harnessing non-covalent interactions to exert control over regioselectivity and site-selectivity in catalytic reactions

Article information

Article type
Perspective
Submitted
16 Ndz 2016
Accepted
05 Nhl 2016
First published
05 Nhl 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 864-877

Harnessing non-covalent interactions to exert control over regioselectivity and site-selectivity in catalytic reactions

H. J. Davis and R. J. Phipps, Chem. Sci., 2017, 8, 864 DOI: 10.1039/C6SC04157D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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