Issue 78, 2017

A two-photon fluorescent probe for ratiometric imaging of endogenous hypochlorous acid in live cells and tissues

Abstract

A fluorescent probe that enables ratiometric imaging of endogenous hypochlorous acid (HOCl) in cells and tissues by two-photon microscopy is developed based on a red-emitting acetyl-benzocoumarin (AcBC) dye. An oxathiolane group in the probe reacts with HOCl to generate the AcBC dye, which involves a ratiometric fluorescence change only toward HOCl along with high sensitivity.

Graphical abstract: A two-photon fluorescent probe for ratiometric imaging of endogenous hypochlorous acid in live cells and tissues

Supplementary files

Article information

Article type
Communication
Submitted
26 Maw 2017
Accepted
06 Ndz 2017
First published
06 Ndz 2017

Chem. Commun., 2017,53, 10800-10803

A two-photon fluorescent probe for ratiometric imaging of endogenous hypochlorous acid in live cells and tissues

Y. W. Jun, S. Sarkar, S. Singha, Y. J. Reo, H. R. Kim, J. Kim, Y. Chang and K. H. Ahn, Chem. Commun., 2017, 53, 10800 DOI: 10.1039/C7CC05834A

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