Issue 83, 2016

Visible-light-mediated generation of nitrile oxides for the photoredox synthesis of isoxazolines and isoxazoles

Abstract

Visible-light photoredox catalysis enables the synthesis of biologically relevant isoxazolines and isoxazoles from hydroxyimino acids. The process shows broad functional group compatibility and mechanistic and computational studies support a visible-light-mediated generation of nitrile oxides by two sequential oxidative single electron transfer processes.

Graphical abstract: Visible-light-mediated generation of nitrile oxides for the photoredox synthesis of isoxazolines and isoxazoles

Supplementary files

Article information

Article type
Communication
Submitted
21 Maw 2016
Accepted
21 Ndz 2016
First published
21 Ndz 2016

Chem. Commun., 2016,52, 12302-12305

Visible-light-mediated generation of nitrile oxides for the photoredox synthesis of isoxazolines and isoxazoles

T. D. Svejstrup, W. Zawodny, J. J. Douglas, D. Bidgeli, N. S. Sheikh and D. Leonori, Chem. Commun., 2016, 52, 12302 DOI: 10.1039/C6CC06029C

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