Issue 55, 2016
From the journal:

Chemical Communications

Predictive recognition of native proteins by cucurbit[7]uril in a complex mixture†

Wei Li,a   Andrew T. Bockus,a   Brittany Vinciguerra,b   Lyle Isaacs*b  and  Adam R. Urbach*a  

* Corresponding authors

a Department of Chemistry, Trinity University, San Antonio, TX, USA
E-mail: aurbach@trinity.edu

b Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA

Abstract

The recognition of human growth hormone (hGH) by the synthetic host molecule cucurbit[7]uril (Q7) was predicted on the basis of its N-terminal phenylalanine. An aqueous-compatible resin with covalently immobilized Q7 groups was prepared and shown to recognize native insulin and hGH in simple and complex mixtures.

Graphical abstract: Predictive recognition of native proteins by cucurbit[7]uril in a complex mixture

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6CC03193E
Article type
Communication
Submitted
16 Dzi 2016
Accepted
10 Kho 2016
First published
10 Kho 2016

Chem. Commun., 2016,52, 8537-8540

Permissions

Request permissions

Predictive recognition of native proteins by cucurbit[7]uril in a complex mixture

W. Li, A. T. Bockus, B. Vinciguerra, L. Isaacs and A. R. Urbach, Chem. Commun., 2016, 52, 8537 DOI: 10.1039/C6CC03193E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements