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We present herein for the first time the synthesis and preliminary biological evaluation of various modified chromanesvia a rosin-derived tertiary amine–thiourea-catalyzed highly enantioselective Friedel–Crafts alkylation reaction.

Graphical abstract: Highly enantioselective Friedel–Crafts alkylation reaction catalyzed by rosin-derived tertiary amine–thiourea: synthesis of modified chromanes with anticancer potency

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