Issue 4, 2024

Pd-Catalysed asymmetric allylic alkylation of heterocycles: a user's guide

Abstract

This review provides an in-depth analysis of recent advances and strategies employed in the Pd-catalysed asymmetric allylic alkylation (Pd-AAA) of nucleophilic prochiral heterocycles. The review is divided into sections each focused on a specific family of heterocycle, where optimisation data and reaction scope have been carefully analysed in order to bring forward specific reactivity and selectivity trends. The review eventually opens on how computer-based technologies could be used to predict an ideally matched catalytic system for any given substrate. This user-guide targets chemists from all horizons interested in running a Pd-AAA reaction for the preparation of highly enantioenriched heterocyclic compounds.

Graphical abstract: Pd-Catalysed asymmetric allylic alkylation of heterocycles: a user's guide

Article information

Article type
Review Article
Submitted
04 Nhl 2023
First published
11 Sun 2024

Chem. Soc. Rev., 2024,53, 1936-1983

Pd-Catalysed asymmetric allylic alkylation of heterocycles: a user's guide

F. Richard, P. Clark, A. Hannam, T. Keenan, A. Jean and S. Arseniyadis, Chem. Soc. Rev., 2024, 53, 1936 DOI: 10.1039/D3CS00856H

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