Issue 36, 2024

Deoxyfluorinated amidation and esterification of carboxylic acid by pyridinesulfonyl fluoride

Abstract

Amide bond synthesis is one of the most used reactions in medicinal chemistry. We report an amide bond formation reaction through deoxyfluorinated carboxylic acids under mild conditions using 2-pyridinesulfonyl fluoride. The reaction procedure has been used in a one-pot synthesis of amides and esters via in situ generation of acyl fluoride. This one-pot synthetic method provides easy access to amides and esters. Using this method, we have sequentially synthesized a tetrapeptide and calceolarioside-B glycoside derivative with good yields.

Graphical abstract: Deoxyfluorinated amidation and esterification of carboxylic acid by pyridinesulfonyl fluoride

Supplementary files

Article information

Article type
Communication
Submitted
23 Yan 2024
Accepted
29 Kul 2024
First published
04 Dzi 2024

Chem. Commun., 2024,60, 4789-4792

Deoxyfluorinated amidation and esterification of carboxylic acid by pyridinesulfonyl fluoride

A. Neeliveettil, S. Dey, V. Nomula, S. Thakur, D. Giri, A. Santra and A. Sau, Chem. Commun., 2024, 60, 4789 DOI: 10.1039/D4CC00877D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements